Generic Actos (Pioglitazone)
Actos (Pioglitazone) is used to control high blood sugar in type 2 diabetes (non-insulin-dependent diabetes mellitus).
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Product Description
Comparison of individual and standard Actoa Actos for C-peptide levels. The primary exposure of interest is treatment with pioglitazone. Tell your doctor if you use insulin. Available for Android and iOS devices. Actos Images. This medication may increase your risk of developing bladder cancer. Weekly news roundup. Retrieved 22 December Food and Drug Administration FDA is informing the public that use of the diabetes medication Actos pioglitazone for more than one year may be associated with an increased risk of bladder cancer. Axtos our patient discussion guide for a list of questions you can ask your doctor. Learn more. Actls the community today. In Actls, other risk factors may further increase your risk of developing bladder cancer, such as:. To address the long-term risk of bladder cancer associated with pioglitazone use, the drug manufacturer Actoss is conducting a ten-year, observational cohort study as well as a nested case-control study in patients with diabetes who are members of Kaiser Permanente Northern California KPNC Acttos plan. Acctos is currently being reviewed. If IGT can be prevented from progressing to overt diabetes, Actos complications can be avoided. Recent studies have demonstrated that life style modification [ 1516 ] and therapy with metformin [ 16 ] and thiazolidinediones [ 141718 ] can prevent or delay the onset of T2DM in high risk subjects. This article has been cited by other articles in PMC. This accurate, reliable and pain-free urine test can give you confidence, reassurance and peace of mind. The primary exposure of interest is treatment with pioglitazone. Medically reviewed by P. The DPP [ 42 ] cited 21 studies with conversion rates percent per year ranging from 2. Actos is a leading medicine in a small class of drugs to treat blood sugar levels in Type II diabetes. Please return to AARP. Prospective randomized trials of thiazolidinediones, including pioglitazone, that have bone density or fracture risk, or both, as outcome measures are lacking. Pioglitazone can cause fluid retention and peripheral edema. Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Therapy with pioglitazone increase the chance of pregnancy in individuals taking oral contraception. Search all BMC articles Search. According to the results of the epidemiological study, the French agency found that patients, who were taking Actos for a long time to aid in type 2 diabetes mellitus, significantly increased risk of bladder cancer compared with patients who were taking other diabetes medications. The risk of hypoglycemia is low in the absence of other drugs that lower blood glucose. Combination with sulfonylureas or insulin reciprocally exponentiate risk of hypoglycemia. Members can take a free confidential hearing test by phone. Posted by WebFX on 19 February am. Blood for measurement of C-reactive protein, adipocytkines, markers of inflammation and other atherosclerotic cardiovascular risk factors was obtained on the final visit while on active treatment, i. Peer Review reports. So, you should contact your doctor as soon as possible if you're concerned about your risk. Medical Management of Type 2 Diabetes. Researchers recommend that people with high-dose and long-term exposure to Pioglitazone receive regular monitoring for bladder cancer. Controlled Clin Trials. FDA has for over a year been informing the public about the dangers associated with its use, nevertheless, the drug is still available in the United States. Get Cxbladder Contact us by phone or email, or fill out an online form and a Cxbladder representative will get back to you. Secondary outcomes i. Charles Grassley, an Iowa Republican who has been pressing for reform at the Food and Drug Administration, said the studies supported the need for a more proactive drug regulation system. Comparison of individual and standard kinetic parameters for C-peptide clearance. The DPP [ 42 ] cited 21 studies with conversion rates percent per year ranging from 2. Posted by The Cxbladder Team on 20 November am. The risk of hypoglycemia is Actos in the absence of other drugs that lower blood glucose. Weekly news roundup. Full size table. Expert Opinion on Pharmacotherapy. Views Read Edit View history. Pioglitazone cannot be used in patients with a known hypersensitivity to pioglitazone, other thiazolidinediones or any of components of its pharmaceutical forms. Facts about pioglitazone Sold as a single-ingredient product under the brand-name Actos. The natural history of T2DM has been well defined [ 10 — 14 ], starting with a genetic predisposition and progression from normal glucose tolerance with insulin resistance to impaired glucose tolerance with superimposition of beta cell failure on insulin resistance, and eventually to overt T2DM characterized by severe beta cell failure and insulin resistance. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Thiazolidinediones have been found to cause bone loss in some rodent models. Mild weight gain is common due to increase in subcutaneous adipose tissue. Medical Management of Type 2 Diabetes. Medicine portal. The Agency will also conduct a comprehensive review of the results from the French epidemiological study. In total, patients received Acgos, and were in the comparison group. Do not be alarmed by the following list of side effects. To preserve study power, the recruitment period was lengthened 3 months to a total of Acctos months to allow recruitment of the targeted number of participants with a commensurate increase in the total study duration for a follow up time of 4 years, starting from the time that the first IGT subject was recruited. If there is a need to consider Actos during your pregnancy, your doctor will discuss with you the benefits and risks of taking Actos. Worried about bladder cancer? View research View latest news Sign up for updates. It is ineffective and possibly harmful in diabetes mellitus type 1 and diabetic ketoacidosis. Data on drug dose, duration of exposure and potential confounding factors are also obtained in the study. FBS has no conflict of interest. Take Actos exactly as prescribed by your doctor. Diabetes Therapy. By using this site, you agree to the Terms of Use and Privacy Policy. Actos is used to treat type 2 Achos in adults aged 18 years or overparticularly those who are overweight. Pediatric Treatment. Patients with bladder cancer prior to study entry or within six months of joining KPNC Actod excluded Actos this study. Use the arrow Acgos to move through the suggestions. American Journal of Physiology. Risk Factors. Recent Public Laws. Questions to Ask about Advanced Cancer. Contact us by phone or email, or fill out an online form and a Cxbladder representative will get back to you. The primary exposure of interest is treatment with pioglitazone. Ask the Pharmacist is written by Armon B. It is available as tablets 15, 30 and 45 mg. Though conflicting results continue to emerge, several studies have found a connection between exposure to the diabetes medication Actos and bladder cancer. Are you alarmed about blood in your urine? Thiazolidinedione use and bone Actoos in older diabetic adults. Metastatic Cancer Research. Information contained in the Ask the Pharmacist column by Dr. Complete an information request form today. Use the arrow keys to move through the suggestions. The tablets should be swallowed with water. Email Address. Your email address is now confirmed. Members can take a free confidential hearing test by phone.
Common use

Actos is used to control high blood sugar in type 2 diabetes (non-insulin-dependent diabetes mellitus). This form of the illness is usually caused by inability of the body to respond correctly to insulin: either the body does not produce enough insulin or the cells ignore the insulin. Insulin is the natural hormone that helps to transfer sugar out of the blood and into the cells, where it is metabolized to energy. Actos works by improving the response of the body to insulin, rather than increasing its insulin output. Actos also reduces the production of unneeded sugar in the liver.

It is possible to use Actos (and rosiglitazone maleate as well) alone or together with insulin injections or other oral diabetes medications such as glipizide, glyburide, metformin hydrochloride.

Dosage and directions

Take this medication by mouth, with or without food, usually one time a daily. Follow all directions of your health care advisor as dosage is based on your medical condition, possible reaction to therapy, and can be corrected if you are treated by other anti-diabetic medications. Take this drug each time the same day as this way you will get the most benefit from it. Regularly monitor blood glucose levels. It may take up to 2 to 3 months before the full benefit is realized. Take all other medications for diabetes according to recommendations of your doctor.


Before taking Actos, tell your doctor or pharmacist if you are allergic to it; if you are allergic to other "glitazones" (such as rosiglitazone, troglitazone); or if you have any other types of allergy. Do not use Actos if you have certain medical conditions. Before to start treatment with Actos, notify you doctor or pharmacist if you have: type 1 diabetes (insulin-dependent diabetes), heart failure (acute congestive heart failure) either newly diagnosed or worsening, dangerously high blood glucose (diabetic ketoacidosis), liver dysfunctions. Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (chronic congestive heart failure), liver problems, fluid in your lungs, swelling (edema), anemia. Extremely low or high blood sugar levels may cause blurred vision, dizziness, or drowsiness; be cautious engaging in activities requiring alertness for example driving or operating machinery. Limit alcohol as much as possible when you are treated with this medication because it can increase the risk of developing hypoglycemia. If you have fever, infection, injury or surgery, it may complicate controlling of your blood sugar. Consult your doctor, as you may need correction of dose or a change in your medication may be required. Women with certain fertility problems may have changes in the menstrual cycle (ovulation) taking this medication. Consult your doctor or pharmacist about prescription of reliable contraception while you are taking Actos. This medication should be used in pregnant women only in life threating conditions. Discuss its risks and benefits with your physician. If you are pregnant your doctor may substitute insulin for Actos. Follow all instructions carefully. There are no reports whether this drug excretes with breast milk. Breastfeeding is not advised while using this drug. Before to start breastfeeding consult your physician.

Possible side effects

Actos side effects include rapid heartbeat, sweating, confusion, blurred vision, headache, numbness or tingling of the mouth, weakness,shakiness, dizziness, tiredness, paleness and sudden hunger.

Missed dose

If you miss a dose, take it as soon as you remember unless just a few hours remained till your next dose. Skip the missed dose and return the dosing schedule in case it is near the time of the next dose. Do not double the dose to make up the dose you missed.


Seek emergency medical attention if you think you have taken too much of this medicine. You may have signs of low blood sugar, such as hunger, weakness, dizziness, headache, irritability, drowsiness, fainting, sweating, confusion, tremors, fast heartbeat, seizure (convulsions), or coma.

Drug interactions

Inform your health care advisor if you are taking any other anti-diabetic medications (insulin, metformin, or sulfonylureas such as glyburide), herbal/natural products (fenugreek, ginseng, gymnema). This medication is able to decrease the effectiveness of certain contraceptives which may result in pregnancy. Take care about additional form of reliable birth control while using Actos. Do not begin or discontinue intake of any medicine without doctor or pharmacist approval.


Store at room temperature in a tight container, away from moisture and humidity.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.