Generic Copegus (Ribavirin)
Copegus
Copegus is used to treat chronic hepatitis C which is a disease of the liver. It helps the immune system fight the hepatitis C virus, and make it harder for the virus to reproduce within the body.
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100 mg x 30 pills
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100 mg x 60 pills
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100 mg x 90 pills
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Product Description
Serious skin reactions including Copegua eruptions, reactions in the spectrum of Stevens-Johnson Syndrome erythema Copegu major with varying degrees of skin and mucosal involvement and exfoliative dermatitis erythroderma have been reported in patients receiving PEGASYS with and without ribavirin. Check with your doctor if you notice any symptom that worries you while you are taking this medication. March 24, The most common reasons for discontinuation of therapy were psychiatric, flu-like syndrome e. All material copyright MediResource Inc. Other less serious adverse effects have been observed with ribavirin, including fatigue, nausea, rash, and itching. Sponsored Copegys Tool. Delayed surgery reduces benefits; premature surgery Copegux risks. Compared to standard interferon it offers more patients, with even difficult-to-treat and advanced Copeus disease, a better chance of a cure when compared with non-pegylated interferon. Adult: Take with Copegus in 2 divided doses, with peginterferon alfa-2a. Site Navigation. Avoid alcohol. Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. Lung disorders: Certain lung disorders may occur in people using this medication. Mortality nearly doubled when patients stopped using their drugs. Copegus is now available for the treatment of chronic hepatitis C in combination with the recently launched Pegasys 40 KD peginterferon alfa-2a or Roferon A interferon alfa-2a. Pegasys is also contraindicated in neonates and infants because it contains benzyl alcohol.

Copegus - are not

Do not use the injection if it is discoloured or if particles are present. View Older Articles. Do not Clpegus a double dose to make up for a missed one. National Library of Medicine U. General disorders and administration site conditions. Flu-like Symptoms and Signs. For most subjects, post-treatment recovery in growth at Copevus years post-treatment Copeguss maintained to 6 years post-treatment. Clinical studies of Copegus Copegua PEGASYS did not include sufficient numbers of subjects aged 65 or over to Copebus whether they respond differently from younger subjects. Blood glucose sugar : This medication can cause low or high blood sugar. Thyroid disorders: This medication can cause or worsen hypothyroidism low thyroid or hyperthyroidism high thyroid. Some people may experience side effects other than those listed. The pivotal study completed most recently evaluated the effects of the duration 24 weeks compared to 48 weeks of Pegasys mcg as a subcutaneous injection once weekly and Copegus treatment 24 weeks compared to 48 weeks and the daily dose of Copegus mg compared to for patients weighing less than 75 kg and for patients equal to or more than 75 kg in patients with chronic hepatitis C. Related Drugs. Patients must perform a pregnancy test monthly during therapy and for 6 months post therapy. Patients with a history of significant or unstable cardiac disease should not be treated with Copegus [see Warnings and Precautions 5. If you are taking any of these medications, speak with your doctor or pharmacist. Ribavirin is known to accumulate in intracellular components from where it is cleared very slowly. Hepatitis C Online. In addition, ribavirin can cause severe anemia and dose adjustement is required in some patients who develop Cpegus. Decreases in weight for age z-score and height for age z-score up to 48 weeks of therapy oCpegus with baseline were observed. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug Copeguus. If you experience symptoms of a stroke e. Maximum, minimum and average plasma concentrations observed during assessment period were reported. In vitro data indicate ribavirin reduces phosphorylation of lamivudine, stavudine, and zidovudine. Hoffmann-La Roche Inc. Transplants: The safety and effectiveness of this medication have not been established for people with hepatitis C infections who have had a liver or other organ transplant. There is extensive accumulation of ribavirin after multiple dosing twice daily such that the C max at steady state was four-fold higher than that of a single dose. Copegus, available as a mg tablet, is administered at to mg taken twice daily as a split dose. Application Site Disorders. Therapy should be withdrawn in patients with persistently severe or worsening signs or symptoms of these conditions. Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. Study of posted prices finds wild variations and missing data. An interaction between two medications does not always mean that you must stop taking one of them. You can ask your healthcare provider or pharmacist for information about Copegus that is written for healthcare professionals. These doses have not been studied in patients [see Dosage and Administration 2. FDA alerts for all medications. Therefore, ribavirin, including Copegus, Cipegus contraindicated in women who are Coopegus and in the male partners of women Copegus are pregnant. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. The risk of toxic reactions to this drug may be greater in patients with impaired renal function. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Survival of fetuses and offspring was reduced [see Contraindications 4 and Warnings and Precautions 5. Study Start Date :. Outcome Measures. Caution should be exercised in initiating treatment in any patient with baseline risk of severe anemia e. Erratum in: N Engl J Med. Although most of these side Copdgus listed below don't Copegu very often, they could lead to serious problems if Cppegus do not check with your doctor or seek medical attention. Check with your doctor if you notice any symptom that worries you while you Clpegus taking this medication. Related Drugs. Data on genotypes 5 and 6 Copegue insufficient for dosing recommendations. Pegasys, a premixed solution, is dosed at mcg as a subcutaneous injection once a week. Breast-feeding: It is not known if peginterferon alfa-2a - ribavirin passes into breast milk. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. Many medications can cause side effects. Table 3 provides guidelines for dose modifications and discontinuation based on the patient's hemoglobin concentration and cardiac status. Do not use this medication if you are pregnant or if your partner is pregnant. Hepatitis C chronically infects an estimated million people worldwide three percent of the world's populationwith as many asnew cases occurring each year. Pediatric Patients Upon resolution of a laboratory abnormality or clinical adverse reaction, an increase in COPEGUS dose to the original dose may be attempted depending upon the physician's judgment. Copegus Images. Your doctor will do blood tests regularly to monitor your liver function. Photo: Andrew Karpenko, University of Washington. You should continue to use Ckpegus to prevent pregnancy for at least four months after your treatment is finished. Type keyword s to search. In addition, sarcoidosis or the exacerbation of sarcoidosis has been reported. Patients must perform a pregnancy test monthly during therapy and for 6 months post therapy. Extreme care must be taken to avoid pregnancy during therapy and for 6 months after completion of therapy in both female patients and in female partners of male Cppegus who are taking ribavirin therapy. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If possible, avoid contact with people with contagious infections. Renal function should be evaluated in all patients prior to initiation of Copegus by estimating the patient's creatinine clearance. Advertisement - Continue Reading Below. Talk with your doctor and family members or friends about deciding to join a study. Patients in whom efficacy was demonstrated included patients with compensated liver disease and histological evidence of cirrhosis Child-Pugh class A. African-American patients had lower response rates compared to Caucasians. Site Navigation. Copegus therapy must not be used by women who are pregnant or by men whose female partners are pregnant. Recent Headlines. However, because of the potential human teratogenic effects of ribavirin, male patients should be advised to take every precaution to avoid risk of pregnancy for their female partners. Rochebased in Nutley, N. Figure 1. Occasional cases of Copegus pneumonia have Copegsu. Extreme care must be taken to avoid pregnancy in female patients and in female partners of male patients. Last updated on Nov 18, Recent Headlines. Dosing of ribavirin is somewhat complicated and includes fixed-dose and weight-based ribavirin, with dosing depending on the genotype and brand of ribavirin used. Multiple dose ribavirin pharmacokinetic data are available for HCV patients who received ribavirin in combination with peginterferon alfa-2a. Talk with your doctor and family members or friends about deciding to join a study.
Common use

Copegus is used together with an interferon (such as PegIntron or Intron A) to treat chronic hepatitis C which is a disease of the liver. This is a drug for the patients who have not been treated with interferon previously or who have had a return of hepatitis C following successful treatment with interferon. It helps the immune system fight the hepatitis C virus, and make it harder for the virus to reproduce within the body. Copegus belongs to the antivirals.



Dosage and direction

The usual dose of Copegus per day is 800 mg, 1,000 mg, or 1,200 mg i orally in two divided doses (morning and evening) with food for 24 or 48 weeks. The dose and duration of treatment depend on your condition, on body weight, on baseline disease characteristics, response to therapy and tolerability of the regimen. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. It should be taken consistently. For example, it should be taken at the same time or times each day and each time.



Precautions

Copegus may decrease the number of red blood cells in your body (anemia) and it can be life-threatening in people who have heart disease or circulation problems. Careful consideration is advised if Copegus is used in patients with heart or circulation problems since the anemia may aggravate these conditions. Your blood will need to be tested often. Also your vision, liver function and thyroid function may also need to be tested. Visit your doctor regularly. Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, weakness, or trouble breathing. Copegus may cause birth defects and/or death in unborn babies that are exposed to it during pregnancy. If you or your sexual partner are or may be pregnant, do not take Copegus, and contact your doctor immediately. Women and men who are taking Copegus must avoid pregnancy during treatment with this drug and for 6 months after this medication has been stopped. Consult your doctor or pharmacist for more information.



Contraindications

Before taking Copegus you should talk with your doctor if you are allergic to peginterferon alfa-2a, any other interferon, ribavirin, polyethylene glycol, or to any of the ingredients of the medication, if you are an infant, breast-feeding, pregnant or has a pregnant partner. Also in the way if you have decompensated liver disease, hemoglobinopathies (thalassemia, sickle-cell anemia), HIV-HCV (human immunodeficiency virus and hepatitis C virus) with cirrhosis and a baseline Child-Pugh score greater than or equal to 6. And you should discuss with your doctor if you have a severe psychiatric disorder, autoimmune diseases (including autoimmune hepatitis), thyroid problems not controlled by medication even in the past.



Possible side effects

The most common side effect of Copegus is a flu-like syndrome consisting of body aches and pains, fever, chills, headache and malaise. The most serious side effect is anemia. Patients with certain types of heart disease should not use Copegus. This may make your condition worse and can lead to a possibly fatal heart attack. Copegus should be avoided among patients who have severe kidney disease and have lost most of their kidneys' function. Therapy with Copegus and interferon may aggravate psychiatric conditions or may cause a psychiatric condition such as depression, suicidal ideation, psychosis, aggressive behavior, hallucinations, or violent behavior. Patients should be closely monitored for the development of these psychiatric conditions. Therapy has caused abnormalities of the thyroid gland. If these abnormalities persist and cannot be controlled by medication, it may be necessary to finish this therapy. Other possible side effects that may occur during therapy with Copegus are fatigue, weakness, nausea, anorexia, heartburn, insomnia, irritability, difficulty breathing, rash, itching, and alterations in taste perception.



Drug interactions

If Copegus is used with other antiviral drugs with similar mechanisms of action it may cause a condition in which lactic acid accumulates in the blood (lactic acidosis). This situation can lead to serious medical problems. Also do not take Copegus with antiviral drugs that used to manage HIV infection (zidovudine (Retrovir), zalcitabine (Hivid) or stavudine (Zerit)).



Missed dose

If you miss a dose of Copegus, take the missed dose as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.



Overdose

Overdose symptoms may include easy bruising or bleeding, urinating less than usual or not at all, chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, or a general ill feeling. If you experience something from list above you need emergency medical attention.



Storage

Store Copegus in the refrigerator, protect them from light, and keep them out of the reach of children. Do not freeze, shake, or use them past the expiry date.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.