Generic Dapsone (Diaminodiphenyl sulfone)
Dapsone
Dapsone is used alone or co-administered with other drugs to treat leprosy and dermatitis herpetiformis (itching lesions on the elbows, knees, and scalp).
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1000 caps x 1 bottle
$328.99
$328.99
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1000 caps x 2 bottles
$547.99
$274.00
$109.98
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1000 caps x 3 bottles
$746.99
$249.00
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Product Description
Daily news summary. July Dapsne vasculitis and sulfone, a case report. Interleukin 8 IL-8 Dapxone, a member of the CXC-chemokine family, purportedly plays an important role, especially in neutrophil-mediated inflammation, but has also been shown to affect other cell species as well e. For topical treatment of acne a twice-daily application is recommended. The inhibitory effect on eosinophil peroxidase could provide at least in part an explanation of the therapeutic efficacy of dapsone in eosinophil-mediated diseases e. Chemotherapy ; —41 Chemotherapy. Dosage reduction to a minimum maintenance level as soon as possible is recommended. Dapsone gel has not been directly compared with more established therapies e. Khan G. Bloody diarrhea—a possible complication of sulfasalazine transferred through human breast milk. Take dapsone exactly as directed. Indian J Lepr. Med J Aust. However, they have been made responsible not only for anti-inflammatory mechanisms e. Journal of the European Academy of Dermatology and Venereology. Allergol Immunopathol Madr ; 40 — Nitro- imidazole derivatives Metronidazole Tinidazole Ornidazole. Linezolid Sutezolid. Reccurent neutrophilic dermatosis Dapwone the dorsal hands [ Dapone. Considering the widespread use of dapsone and the paucity of reports, and in line with this results of the metaanalysis HS to dapsone is not a rare adverse effect. Life Sci. Therefore, this issue has been omitted from this survey. In conclusion, dapsone inhibits chemotaxis, but only when certain stimuli are applied. Am Rev Respir Dis. Complement system, coagulation and fibrinolytic system, cutaneous proteases In vitro, an inhibitory effect of dapsone on the alternative way of complement activation was detected [Millikan et al. Immunol Ser. Therefore, this issue has been omitted from this survey. Transfer of a Grant. Research Funding Opportunities. Levels of Evidence: Cancer Genetics. Venom-induced inflammation following the bite of the brown recluse spider loxosceles reclusa Dapsone been linked to an activation of membrane phospholipids. Amikacin Kanamycin Streptomycin. Alvogen, Inc. As the dapsone concentrations used in this study resemble that attained in vivo, this action might be useful in the therapy of diseases with AIP dysfunction. Advisory Board Meetings. Dapsone has been use as a monomer in the design of dye adsorbent polymers. In vivo studies produced inconsistent results. Recently, dapsone was also investigated in retrospective or randomized non-blinded trials [ 1424425375 ]. References 1. Bottom Line Topical dapsone gel will decrease the percentage of lesions in patients with mild to moderate acne, especially inflammatory lesions. Dapsone should be administered as part of combination therapy for prophylaxis of toxoplasmosis. Thus, there is the possibility that PMN in peripheral blood are exposed both to dapsone and its metabolites. External link. Hocking DR. Contributing to Cancer Research. Precautions: Pre-existing severe anaemia should be treated before dapsone therapy is started. As subsequent studies demonstrated, this might be attributed to calcium mobilization [ ]. Login or Register. It has to be pointed out, however, that the dapsone concentrations used in this study exceed that under therapy. After absorption, dapsone undergoes enterohepatic circulation. However, it has to be stressed that glucosephosphate dehydrogenase G6PD -deficient patients are less susceptible to met-Hb production, but more susceptible to haemolysis. This step is mediated by uridine diphosphate UDP -glucuronosyltransferase. The effect of O-tetradecanoylphorbolacetate TPA on phospholipid metabolism of human epidermal keratinocytes in culture. J Neurooncol. Other names. Prospective randomized non-blinded clinical trial on the use of dapsone plus antihistamine vs. Dapsone: unapproved uses or indications. Pemphigus vulgaris in pregnancy: analysis of current data on the management and outcomes. This has led to a discussion among haematologists whether dapsone should be classified as second-line therapy for patients with ITP. The awkward case of 'his or her'. Bozmen et al. J Neurosci Res. Drug Metab Dispos. Published : 11 August Results of therapy studies with anti-inflammatory substances in occlusive conditions in psoriasis. Dapsone hydroxylamine inhibits the LTB4-induced chemotaxis of polymorphonuclear leukocytes into human skin: results of a pilot study. Liver function tests revealed total bilirubin Treatment of Dapspne complications. Conclusions In summary, aDpsone report a case Dapwone dapsone syndrome with an unusual hepatic manifestation. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. Cancer Statistics. Prior Approvals. Hepatocellular injury is characterized by elevated transaminases with liver biopsy showing predominantly eosinophilic lobular and portal infiltration. Tell each of your healthcare providers about all your medical conditions, allergiesand all medicines you use. Itha, S. Therapy should be continued on a life-long basis. We comply with the HONcode standard for trustworthy health information - verify here. Other less common reactions include headache, nervousness and insomnia. There was no edema of face or limbs. Last updated: December 1, Email Alerts Don't miss a single Dapsonee. Log In. Dapsone has been used in Dapsine treatment of bullous pemphigoid BP for over 50 years. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Studies show that dapsone gel has modest effectiveness in the treatment of moderately severe inflammatory and noninflammatory acne. A daily clinical dose 1CD of dapsone taken to be equivalent to that used in humans was 1. Dapsone Rev Respir Dis. J Clin Immunol. Reprints and Permissions. Annual Report to the Nation. Earn up to 6 CME credits per issue. Dapsone hydroxylamine induces premature removal of human erythrocytes by membrane reorganization and antibody binding. Dapsone has been used in the treatment of bullous pemphigoid BP for over 50 years. Using Trusted Resources. Br J Haematol. Already a member or subscriber? J Eur Acad Dermatol Venereol. In another experiment, the same group examined the mitochondrial complex V of Caenorhabditis elegans C.
Common use

Dapsone is anti-infective medication used in combination with rifampicin and clofaziminein treatment of dermatitis herpetiformis (a skin condition) and leprosy (Hansen's disease) caused by Mycobacterium leprae, pneumonia caused by Pneumocystis jiroveci. In combination with pyrimethamine it is used to treat malaria



Dosage and direction

Take Dapsone with a full glass of water. To decrease upset stomach symptoms you may take this medication with food. Take this drug about each time the same day to get the most benefit from it. The dose of Dapsone depends on your condition. To treat leprosy in adults take 50-100 mg orally once daily for 2-5 years. Take 50 mg of Dapsone orally once daily to treat dermatitis herpetiformis. The recommended dose may be increased to 300 mg a day. To treat pneumocystis pneumonia in adults take 100 mg orally one time a day for two or three weeks. Follow all instructions of your doctor. Do not take more Dapsone than it was recommended.



Precautions

This medication may cause rare but fatal liver or blood problems which are characterized by such signs as bruising or pinpoint red spots on the skin, sore throat, fever, pale skin, jaundice and especially rash. Contact your doctor immediately if you experience the symptoms listed above. In rare cases may lead to serious, and even fatal, skin reactions. Inform your doctor if you have methemoglobin reductase deficiency (hemoglobin M), glucose 6-phosphate dehydrogenase (G6PD) deficiency, liver disease. Avoid exposing of your body to direct sun rays as this medication may cause increased skin sensitivity.



Contraindications

Do not use Dapsone in patients with hypersensitivity to the drug.



Possible side effect

If any sign of allergic reaction appear contact your doctor immediately. These include hives, rash, facial swelling, difficulty breathing. Inform your doctor immediately if you have pale skin, bruising or pinpoint red spots on the skin, sore throat, fever, jaundice, muscle weakness, numbness or tingling, bluish skin color, abdominal pain, difficulty breathing, unusual tiredness, dark colored urine or pale colored stools.



Drug interaction

Rifampin decreases blood levels of Dapsone. Folic acid antagonists such as pyrimethamine increase possibility of hematologic reactions.



Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.



Overdose

If you have such symptoms as excitation, seizures, nausea, vomiting, and bluish skin color contact your doctor immediately or seek emergency medical help.



Storage

Store tablets at room temperature between 15-30 C (59-86 F) in a dry tight container away from moisture and sunlight.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.