Generic Depakote (Divalproex)
Depakote
Depakote is used to heal seizure disorders, convulsions, to prevent migraine and treat acute manic episodes associated with bipolar disorder.
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Product Description
Article continues below Concerned about Bipolar Disorder? Do not stop using Depakote suddenly, even if you feel fine. Valproic Acid. Overdose symptoms can include irregular heartbeat, sleepiness, and loss of consciousness resulting in a coma. The syrup, capsules, delayed-release tablets, and sprinkle capsules are usually taken two or more times daily. Search for terms x. Archived Depakots from the original on It is also important information to carry with you in case of emergencies. What side effects Depwkote Depakote cause? An overdose of Depakote could be fatal, so seek immediate help or call the Poison Help Line at if you overdose. Antiepileptic medications have also shown to lower folate levels. Your doctor will probably tell you not to take valproic acid. This includes prescription and over-the-counter medicines, vitaminsand herbal products. It also is recommended that you wait to drive or operate machinery until you know how the medication affects you. The typical patient would progress from irritation to screaming, door-slamming, property destruction or fighting explosively, i. It was approved to treat bipolar disorder inand in it was approved for use as a migraine prevention medication. See also: List of adverse effects of valproic acid and List of adverse effects of valproate semisodium. How should this medicine be used? If you have any questions about AbbVie's Depakote. Instead, the best way to dispose of your medication is through a medicine take-back program. Double-blind placebo-controlled trials have been negative. You should not take Depakote if you have a history of liver disease, a urea cycle disorder, or a genetic disorder such as Alpers' disease a progressive degenerative disease of the central nervous system that occurs mostly in infants and childrenor Alpers-Huttenlocher syndrome the formal name for Alper's Disease. Your dose may need to be changed if you do not get enough fluids each day. What is Depakote? Keep all follow-up visits with your healthcare provider as scheduled. If you have any questions about AbbVie's Depakote. CRC Press. Acta Neurol. I take 1, mg daily. Familial adenomatous polyposis. Alphapharm Pty Limited. Washington Post. Depakote Images. Depakote is used as therapy for seizures and also for behavioral issues related to bipolar disorder. Wear protective clothing and use sunscreen SPF 30 or higher when you are outdoors. When you use this card, you are confirming that you have not submitted and will not submit a claim for this prescription for reimbursement under any federal, state, or government-funded healthcare program, such as Medicare including Part DMedicare Advantage, Medicaid, Medigap, Veterans Affairs, the Department of Defense, or TRICARE. Women who are pregnant should only take valproic acid to treat seizures or bipolar disorder manic-depressive Depakote a disease that causes episodes of depression, episodes of Depamote, and other abnormal moods if other medications Depakore not successfully controlled their symptoms or cannot be used. Because this medication can be potentially harmful to the fetus, valproate should be considered for those able to become pregnant only after the risks have been discussed. This rebate form is not available to individuals who are paying cash for their prescription or who are receiving prescription reimbursement under a state or federally funded insurance program. Are there any major differences between Depakote and other antipsychotics used to treat bipolar disorder? Gharbia, PharmD. Depakote ER [package insert]. See also: List of adverse effects of valproic acid and List of Ddpakote effects of valproate semisodium. This information is for Depakote purposes only, and not meant to provide medical advice, treatment, or diagnosis. Tablets and capsule shown are not actual size. Acute myeloid leukaemia. Valproic acid can cause serious birth defects physical problems that are present at Depxkoteespecially affecting the brain and spinal cord and can also cause lower intelligence Dpeakote problems with movement and coordination, learning, communication, emotions, and behavior in babies exposed to valproic acid before birth. It is important to follow up with your doctor for blood work and to contact your doctor immediately if you notice abdominal pain, sudden nausea or vomiting, or changes in mood or behavior. Epileptic Disorders. Take the missed dose as soon as you remember it. Other birth defects can affect the structures of the heart, head, arms, legs, and penis and can lower IQ. This information is for educational and informational purposes only and is not medical advice. Do not stop taking valproate, even when you feel better. Your dose may need to be changed if you do not get enough fluids each day. Offer subject to change or discontinuance without notice. Impulse control disorder. Are there any major differences between Depakote and other antipsychotics used to treat bipolar disorder? I ask this because I must avoid alcohol and too much caffeine and I must east properly at all times. If you are taking the sprinkle capsules, you may notice the medication beads in your stool. You should also be aware that the linked site may be governed by its own set of terms and conditions and privacy policy for which AbbVie has no responsibility. Journal of Child Neurology. For general information, Learn About Clinical Studies. Amiloride Benzamil Triamterene. Call your healthcare provider between visits as needed, especially if you Depakote worried about symptoms. The FDA warns that women who take this drug should use effective birth control to prevent pregnancy. You are encouraged to report negative side effects of prescription drugs to the FDA. Anticonvulsants are sometimes taken to treat the manic episodes associated with bipolar disorder. Message and data rates may apply. Laura Cable, PharmD. Take the dose of Depakote when you remember, but skip the missed dose if it is almost time for your next dose. Only tea and exercise has helped me sleep properly. This rebate form is not available to individuals who are paying cash for their prescription or who are receiving prescription reimbursement under a state or federally funded insurance program. Shereen A. Nonetheless, it is still not clear what alternative pharmacological treatments for temper driven by irritable mood swings are available.

Depakote - think

For many decades, its Depaote use was in laboratories as a "metabolically inert" solvent for organic compounds. Other names. TGA eBusiness Services. Limited depends on the seizure type; it can help with certain kinds of seizures: drug-resistant epilepsy, partial and absence seizures, can be used against glioblastoma and other tumors both to improve survival and treat seizures, and against tonic—clonic seizures and status epilepticus. Sodium valproate has been associated with the rare condition paroxysmal tonic upgaze of childhood, also known as Ouvrier—Billson syndrome, from childhood or fetal exposure. Clin Epigenetics. Do you wish to leave this site?. Do not crush, chew or split tablets. Depakote belongs to the class of medications known as anticonvulsants. This medicine is an anticonvulsant that works in the brain tissue to stop seizures. The recommendation is to talk with your health care provider to determine if any additional vitamins should be taken beyond a multivitamin. Other side effects reported with Depakote include hypertension high blood pressure and hypotension low blood pressure. Q: I take Tegretol and Depakote for epilepsy. Retrieved You should never take extra doses of the medication to make up for missed doses. Depakote can cause liver damage, and the risk is more likely to occur during the first 6 months of taking the medication. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. What do I do if I miss a dose? Mitochondrial Disease Patients with mitochondrial disease caused by a certain DNA mutation are at an increased risk of acute liver failure and resultant death. Beth Isaac, PharmD. Depakote is sometimes prescribed when patients experience rapid cycling of mood episodes and works by calming the hyperactivity of the brain during mania. In some cases liver damage continued even after patients stopped taking Depakote. Depakote is used to treat various types of seizure disorders. Call your doctor at once if the person taking this medicine has signs of liver or pancreas problems, such as: loss of appetite, upper stomach pain that may spread to your backongoing nausea or vomiting, dark urine, swelling in the face, or jaundice yellowing of the skin or eyes. A: Studies have shown that Depakote can cause birth defects. For any immediate concerns, consult your physician. Q: Does Depakote taken over years ruin your liver?
Common use

Depakote contains Divalproex sodium, the substance which interacts with certain substances in the brain and increases the concentration of gamma-aminobutyric acid (GABA), which is a neurtransmitter. The drug is used to treat seizure disorders, the manic phase of bipolar disorders, to prevent migraine headaches.



Dosage and direction

The recommended initial dose for treatment of acute mania due to bipolar disorder is 750 mg daily taken in divided doses. For prevention of migraines take 250 mg twice daily. To treat seizures take initial dose calculated as 10-15 mg/kg/day, the dose should be increased gradually by 5-10 mg/kg/day every week to achieve the desired effect. Do not exceed the recommended dose and follow all recommendations of your health care advisor. Drink plenty of water during treatment. Liver function should be controlled on a regular basis to avoid harmful effects. Swallow the pill whole, do not crush or chew it. Inform your doctor immediately if you suppose that the medication does not work properly to prevent seizures. Do not stop taking the medicine without your doctor's permission even if you feel better.



Precautions

Life-threating hepatic failure may develop, this is most likely to occur in children under two years of age especially if they if they have a metabolic disorder or a brain disease causing mental impairment (multiple sclerosis, Huntington disease, Creutzfeldt-Jacob disease, a brain injury or infection). Liver failure symptoms include malaise, lethargy, weakness, facial edema, vomiting, anorexia. Depakote also may cause rare cases of pancreatitis resulting in fatalities, which may suddenly appear even after several years of treatment with Depakote. Dose adjustment is needed in the patients with a bleeding or blood clotting disorder, a history of brain disorder, head injury, or coma, a family history of a urea cycle disorder, a family history of infant deaths with unknown cause, HIV or CMV (cytomegalovirus) infection. Suicide thoughts are also possible during treatment with the drug.



Contraindications

The medication cannot be administered to the patients with hepatic diseases, significant hepatic dysfunction known urea cycle disorders.



Possible side effect

The most common reported side effects are: nausea, somnolence, dizziness, vomiting, asthenia, abdominal pain, dyspepsia, rash, diarrhea, weight loss, tremors, low fever, dark urine, clay-colored stools. In some cases alopecia (loss of hair), itching and sensitivity to sunlight occur. More rare but serious adverse reactions include pancreatitis, liver injury, and abnormal bleeding. Liver is more likely to occur in children. The risk increases when a patient is taking two more more anti-seizure drugs. Symptoms of damaged liver are malaise, weakness, jaundice, swelling in the face, vomiting, loss of appetite.



Drug interaction

The following drugs may interact with Depakote: topiramate (Topamax), tolbutamide (Orinase), a blood thinner such as warfarin (Coumadin), aspirin or acetaminophen (Tylenol), clozapine (Clozaril, FazaClo), diazepam (Valium), zidovudine (Retrovir), meropenem (Merrem), rifampin (Rifadin, Rimactane, Rifater), ethosuximide (Zarontin), indomethacin (Indocin), nabumetone (Relafen), ibuprofen (Motrin, Advil), naproxen (Naprosyn, Aleve), diclofenac (Voltaren, Cataflam, Arthrotec), ketorolac (Toradol) and aspirin. Such medicines as warfarin or heparin if used concomitantly with Depakote may affect blood clotting and lead to abnormal bleeding. Aspirin and felbamate (Felbatol) reduce catabolism of Depakote and hereby increase its blood concentrations. On the contrary phenytoin (Dilantin), Rifampin (Rifadin; Rimactane), carbamazepine (Tegretol) reduce its blood concentrations. Absorptin of Depakote is reduced by Cholestyramine (Questran), therefore intake of Depakote should be separated by at least two hours before or six hours after doses of cholestyramine.

Depakote can significantly increase concentrations in blood of lamotrigine (Lamictal), zidovudine (AZT), ethosuximide (Zarontin), diazepam (Valium) and phenobarbital, thereby increasing their concentrations in blood.



Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.



Overdose

Depakote overdose symptoms include weak pulse, drowsiness, shallow breathing, somnolence, heart block, loss of consciousness, and deep coma. In case of the suspected overdose contact your doctor immediately and seek for immediate medical attention.



Storage

Store at room temperature 15-30 C (59-86 F) away from moisture and heat.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.