Generic Detrol La (Tolterodine)
Detrol La
Detrol La is prescribed for treatment of spasms of the bladder muscles, overactive bladder characterized by symptoms of urinary urgency, frequency, and incontinence.
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4 mg x 10 pills
$55.99
$5.60
$0.00
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4 mg x 30 pills
$144.99
$4.83
$23.10
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4 mg x 60 pills
$266.99
$4.45
$69.00
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4 mg x 90 pills
$367.99
$4.09
$135.90
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4 mg x 120 pills
$445.99
$3.72
$225.60
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Product Description

Improbable: Detrol La

Cycrin Daily news summary. An estimated 33 million Americans over the age of 18 suffer from OAB, a medical condition which studies have found disrupts daily activities and sleep, and can negatively impact patients' mental health. Detrusor overactivity DO, contraction of the muscular bladder wall Detrol La the most common form of urinary incontinence Detril in older adults. Serious adverse events affecting the Dstrol tract, nervous system and cardiovascular system are reported infrequently in patients treated with DETROL LA. Bucheon-si, Gyunggi-do, Korea, Republic of, To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. The primary metabolic route involves the oxidation of the 5-methyl group and is mediated by the cytochrome P 2D6 CYP2D6 and leads to the formation of a pharmacologically active metabolite, 5-HMT. However, the confidence intervals overlapped. Carcinogenicity studies with tolterodine were conducted in mice and rats. CYP2D6 extensive metabolizers had low serum concentrations of tolterodine and high concentrations of the active metabolite 5-HMT, while poor metabolizers had high concentrations of tolterodine and negligible active metabolite concentrations. This helps your doctor determine if Detrol LA is the right medication for you. All rights reserved. This is not a complete list of side effects and others may occur. Search for terms x. Swallow it whole. Contact Us. Interactive image. Dextrallorphan Dextromethorphan Dextrorphan Racemethorphan Racemorphan. Last Update Posted : March 15.
ZANAFLEX More Information. A Dehrol of pediatric patients on DETROL LA, on placebo aged 5—10 with urinary frequency and urge incontinence were studied in two randomized, placebo-controlled, double-blind, week studies. State College, Pennsylvania, United States, This is a repackaged label. By reducing the number Detrlo intensity of involuntary bladder muscle contractions, DETROL LA also reduces the strong sensation of urinary urgency and the number of voiding episodes associated with overactive bladder. Actual Study Completion Date :. In another clinical study, elderly volunteers aged 71 through 81 years were given tolterodine immediate release 2 or 4 mg 1 or 2 mg bid. Helena St. Read our disclaimer for details. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. No single QT correction method is known to be more valid than others. Do not take in larger or smaller amounts or for longer than recommended.
Detrol La 333
Sinemet Symmetrel
Call your doctor for medical Ddtrol about Lw effects. The results Detol recently published in the journal Drug Safety. Common side effects include headache, dry mouth, constipation, and dizziness. The clearance of orally administered tolterodine immediate release was substantially lower in cirrhotic patients 1. Mean C max of tolterodine immediate release 1. It is not known whether tolterodine passes into breast milk or if it Derrol harm a nursing baby. Related Drugs. C max and area under the concentration-time curve AUC determined after dosage of tolterodine immediate release are dose-proportional over the range of 1 to 4 mg. When taken as directed, the active ingredient called Tolterodine Tartrate Extended Release will block cholinergic receptors located on the surface of the muscle cells. The primary metabolic route involves the oxidation of the 5-methyl group and is mediated by the cytochrome P 2D6 CYP2D6 and leads to the formation of a pharmacologically active metabolite, 5-HMT. Aggressive, abnormal and hyperactive behavior and attention disorders occurred in 2. The main effects following a 6. In vivo drug-interaction data show that tolterodine immediate release does not result in clinically relevant inhibition of CYP1A2, 2D6, 2C9, 2C19, or 3A4 as evidenced by lack of influence on the marker drugs caffeine, debrisoquine, S-warfarin, and omeprazole. Tell your doctor about all medications you use. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Follow the directions on your prescription label. For general information, Learn About Clinical Studies. Common side effects include headache, dry mouth, constipation, and dizziness. Tolterodine acts on M 2 and M 3 [7] subtypes of muscarinic receptors whereas older antimuscarinic treatments for overactive bladder act more specifically on M 3 receptors. FDA Resources. Send us your comments by March 14, Other Notes. This may contribute to greater patient satisfaction with treatment, resulting in patients staying on treatment longer. The urge to urinate becomes almost desperate and you must get to a restroom immediately even though you know your bladder is not full. Other Notes. Overactive Bladder OAB. The generic alternative is not manufactured by the company that makes the brand product. Skip to Content. Medically reviewed by Drugs. Get emergency medical help if you have any of these signs of an allergic reaction: hives ; difficulty breathing; swelling of your face, lips, tongue, or throat. Clinical Results Three placebo-controlled, 12 week studies were held involving a total of patients who received Detrol 2 mg twice daily and patients who received the placebo. Detrusor overactivity DO, contraction of the muscular bladder wall is the most common form of urinary incontinence UI in older adults. Retrieved 6 June Detrol is present in the breast milk of nursing mice.
Common use

Detrol La contains tolterodine tartrate, the substance of cholinergic (acetyl-choline) receptor blockers class. The medication is used to reduce spasms of the bladder muscles, overactive bladder with symptoms of urge urinary incontinence, and frequency.



Dosage and direction

Detrol La is taken two times a day. The recommended initial dose is 2mg taken twice daily. Treatment by long-acting Detrol La should be started by 4mg daily dose. If it is not well tolerated it should be reduced to 2mg. Dose adjustment is needed for the patients with impaired liver or kidney function. Do not open Detrol La capsules, do not crush or chew them. Swallow the tablet whole.



Precautions

Discuss with your doctor about following conditions you may have: glaucoma, kidney or liver disease, myasthenia gravis, or a personal or family history of "Long QT syndrome." This medicine may change your thinking reactions or ability to concentrate. Be careful while driving or operating machinery.



Contraindications

Detrol La cannot be used to treat patients with uncontrolled narrow-angle glaucoma, obstruction to the flow of urine (urinary retention), poor emptying of the stomach (gastric retention), allergic reaction to the components of the drug in history.



Possible side effect

Besides allergic reactions (hives, facial swelling, rash, skin eruptions, difficulty breathing) Detrol La may cause chest pain, fast or uneven heart rate, confusion, painful or difficult urination, hallucinations, urinating less than usual or not at all.



Drug interaction

Inform your doctor about all prescribed and over-the-counter medications you are using and especially about the drugs which may interfere with elimination of tolterodine by the liver which include: cyclosporine (Gengraf, Neoral, Sandimmune), clarithromycin (Biaxin), azithromycin (Zithromax), erythromycin, telithromycin (Ketek), pentamidine (NebuPent, Pentam), sparfloxacin (Zagam), itraconazole (Sporanox), ketoconazole (Nizoral), and miconazole (Monistat, Micatin), arsenic trioxide (Trisenox), chloroquine (Arelan) or halofantrine (Halfan), levomethadyl (Orlaam), or methadone (Dolophine, Methadose), vinblastine (Velban), medications used to treat psychiatric disorders such aschlorpromazine (Thorazine), mesoridazine (Serentil), pimozide (Orap), haloperidol (Haldol), or thioridazine (Mellaril), heart rhythm medicine such as disopyramide (Norpace), procainamide (Procan, Pronestyl), amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), sotalol (Betapace), quinidine (Cardioquin, Quinaglute).



Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.



Overdose

Symptoms of overdose include blurred vision, dry mouth, and fast heartbeat.



Storage

Store at room temperature 15-30 C (59-86 F) away from moisture and heat.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.