Generic Glucotrol Xl (Glipizide)
Glucotrol Xl
Glucotrol Xl is sulfonylurea class of drugs, a drug used to treat type 2 of diabetes.
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Product Description

Glucotrol Xl - cannot tell

Dosage adjustments in patients receiving glipizide extended-release Glucohrol may be Gluotrol at approximately 3-month intervals, based on HbA 1c measurements. Drugs that may decrease the hypoglycemic effect of sulfonylurea antidiabetic agents, including glipizide, include nonthiazide diuretics e. Oral cimetidine Glucotrop been shown to substantially increase the area Glucottol the plasma glipizide concentration-time curve and was associated with a substantial reduction in the postprandial increase in blood glucose concentration in diabetic patients receiving the drugs concomitantly. For the Glucotrol Xl experience on our site, be sure to turn on Javascript in your browser. When the commercially available fixed-combination preparation is used as second-line therapy in patients with type 2 diabetes mellitus whose blood glucose is not adequately controlled by therapy with a sulfonylurea antidiabetic agent or metformin alone, the recommended initial dosage in previously treated patients is 2. These drugs can cause low blood sugar when taken with glipizide. In the UKPD studies, stepwise addition of insulin or metformin to therapy with maximal dosage of a sulfonylurea was required periodically over time to improve glycemic control. Drug Status Rx. Maintenance dosage of glipizide should be conservative in debilitated, malnourished, or geriatric patients or patients with impaired renal or hepatic function because of an increased risk of hypoglycemia in these patients. Distribution of glipizide into human body tissues and fluids has not been fully characterized. Nausea or vomiting was reported in 0. Initial Dosage in Previously Untreated Patients For the management of type 2 diabetes mellitus in patients not previously receiving insulin or sulfonylurea antidiabetic agents, the recommended initial adult dosage of glipizide is 5 mg daily as conventional or extended-release tablets; in geriatric patients or those with hepatic disease, an initial dosage of 2. A computational fluid dynamic-based model was developed to quantitatively describe the drug transport in the capsule matrix and the drug release process. It comes as an oral immediate-release tablet and oral extended-release tablet. However, they have shown some low blood sugar effects in newborns. You should always consult your doctor or other healthcare professional before taking any medication. Oral antidiabetic agents are not effective as sole therapy in patients with type 1 diabetes mellitus; insulin is necessary in these patients. Are breastfeeding or plan to breastfeed. When glipizide is added to therapy with other antidiabetic agents, glipizide extended-release tablets may be initiated at a dosage of 5 mg daily. If cimetidine is administered concomitantly with glipizide, the patient should be closely monitored for signs and symptoms of hypoglycemia; dosage adjustment of glipizide may be necessary when cimetidine therapy is initiated or discontinued. The uptake and erosion study, the correlation coefficient R and the exponent n were used as indicators to justify drug release mechanism. The second oral antidiabetic agent should be added to glipizide at the lowest recommended dosage, and patients should be observed carefully. Patients with diabetes mellitus who have elevated HbA 1c concentrations despite having adequate preprandial glucose concentrations should monitor glucose concentrations hours after the start of a meal. Pediatric Use 8. Centers for Disease Control and Prevention, nearly 1 in 5 of the nearly 18 million Americans who provide informal, unpaid care may be in fair or poor health. Studies characterizing the pharmacokinetics of glipizide in pediatric patients have not been performed. Finally, the design space was found. Compression-coated tablets of glipizide using hydroxypropylcellulose for zero-order release: in vitro and in vivo evaluation. Glipizide is also contraindicated in patients with known hypersensitivity or allergy to the drug. SKU Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:. Are You At Risk? Pack Size - Price If you take more than 20 mg of immediate-release tablets, your dosage of the extended-release tablets will be 20 mg. The safety and efficacy of switching from combined therapy with separate preparations of glipizide or another sulfonylurea antidiabetic agent and metformin hydrochloride to the fixed-combination preparation containing these drugs have not been established in clinical studies. This drug may increase your blood Gluotrol levels when taken Glucotgol glipizide. Subscribe to Drugs. Thiazide Diuretics Thiazide diuretics may exacerbate diabetes mellitus, resulting in increased requirements of sulfonylurea antidiabetic agents, temporary loss of diabetic control, or secondary failure to the antidiabetic agent. Patients should be informed of the potential risks and advantages of glipizide therapy and alternative forms of treatment. On the operation, it turned out that the left kidney is normal. Type 2 diabetes was long thought to be an adult disease, but more young people are being diagnosed with the metabolic disorder. The sixties and seventies are known for many things, but perhaps one of the lesser-known events was the reclassification of the hallucinogen, psilocybin commonly found in magic mushroomsas a Class A drug. Limitations of Use: Not for treating type 1 diabetes or diabetic ketoacidosis. The decision to switch to the nearest equivalent dosage versus re-titration should be individualized using clinical judgment. Caring for a loved one at home can be rewarding, but it can also be overwhelming and take a toll on your own health, a new study suggests.
Common use

Glipizide is sulfonylurea class of drugs a drug used to treat type 2 of diabetes and belongs to sulfonylurea class of drugs together with glimepiride (Amaryl), glyburide (Micronase, Diabeta), tolbutamide (Orinase) and tolazamide (Tolinase). It stimulates insulin secretion by beta-cells of pancreas.

Dosage and direction

Do not change your dose of Glipizide without first talking to your doctor. A starting dose when for immediate release tablets is 5 mg which should be taken 30 minutes before a meal. The maximum dose is 40 mg daily. Maximum dose of extended release tablets should not exceed 20 mg daily. Take it with a full glass of water before a meal. The best result of treatment is achieved when this medication is taken on a regular basis.


Treatment with Glipizide may increase the risk of death from cardiovascular disease. Avoid drinking alcoholic beverages as it lowers blood sugar. Do not chew, divide, or crush extended release tablets of Glipizide, swallow them whole.


Hypersensitivity, insulin-dependent diabetes mellitus (juvenile diabetes, diabetes, accompanied by ketoacidosis or precoma) severe kidney or liver failure, stenosis of the gastrointestinal tract, infancy.

Side effects

Besides signs of allergy (hives, rash, swelling of face and tongue) in some patients other symptoms are described: headache, dizziness, diarrhea, gas, hepatitis, jaundice, and a low sodium concentration.

Drug interaction

Alcohol delays effects of Glipizide by slowing its absorption. Glipizide should be administered 1-2 hours before cholestyramine as the latter affects its absorption. Fluconazole (Diflucan) increases absorption and effectiveness of Glipizide. Medications which lower and rise blood sugar are able to change Glipizide effect: aspirin or another salicylate, nonsteroidal anti-inflammatory drugs, sulfa-based drugs such as sulfamethoxazole-trimethoprim (Bactrim, Septra), MAO- inhibitors, beta-blockers such as propranolol (Inderal), thiazide diuretics, steroid medicines such as prednisone (Deltasone, Orasone),estrogens, corticosteroids, thyroid medicines, phenothiazines such as chlorpromazine (Thorazine), niacin, phenytoin, and calcium channel blocking drugs.

Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or time for your next dose is in a short while. Do not take double doses of this medication or extra doses of it. Take your usually dose next day in the same regularly time.


Symptoms of Glipizide overdose are ones of low blood sugar: hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, and coma. If you experience one of them or any unusual symptoms call your doctor immediately.


Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.