Generic Indinavir (Indinavir Sulfate)
Indinavir
Indinavir is used to treat HIV infection.
Package
Price
Per Pills
Savings
400 mg x 30 pills
$159.99
$5.33
$0.00
Buy Now
Next orders 10% discount
400 mg x 60 pills
$254.99
$4.25
$64.80
Buy Now
Next orders 10% discount
+ Free standard airmail service
Product Description
Indinavir can also cause kidney stones, but drinking a minimum of 1. Indinavir should be taken on an empty stomach or with a light snack, but not within 1 hour before or 2 hours after a full meal. These include reduced binding affinity between the inhibitor and the protease enzyme, alterations in enzyme catalysis, effects on dimer stability, alterations in inhibitor binding kinetics and re-shaping of the active site. Production of this Web site has been made possible through a financial contribution from the Public Health Agency of Canada. Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Study Description. You should be aware that alcohol and caffeine can dehydrate your body. Implications of resistance to other antiretrovirals for indinavir treatment. Indinavir, sold under the brand name Crixivan, is a type of anti-HIV drug antiretroviral called a protease inhibitor PI. When indinavir is used as the only protease inhibitor in a regimen, for best absorption, this drug should be taken with water on an empty stomach, that is, either one hour before or two hours after a meal. Indinavir is used along with other medications to treat human immunodeficiency virus HIV infection. Interactions with Other Drugs Indinavir is an inhibitor of cytochrome P 3A4 CYP3A4and may alter serum concentrations of other drugs metabolized by this pathway, including certain benzodiazepines, cholesterol-lowering agents, ergot derivatives, rifampin, phosphodiesterase type 5 PDE5 inhibitors sildenafil, tadalafil, or vardenafiland others. Indinavir interferes with an enzyme called protease, which is used by HIV-infected cells to make new viruses. It should be kept in a tight container so that it is kept away from moisture. Most side effects from indinavir are manageable, but a few can be serious. Later on, Merck faced serious backlash from community members who though did not like the pricing and distribution of the drug. Brand names Other names. Genotypic or phenotypic testing may be useful in predicting the likelihood of response to other protease inhibitors following failure of regimens containing indinavir. It was the eighth antiretroviral approved by the FDA after being studied in more than 2, patients. These were similar to existing inhibitors. The studies showed improvements in markers of HIV disease progression including large viral load decreases and count improvements of CD4, a glycoprotein. By using this site, you agree to the Terms of Use and Privacy Policy. This situation of limited supply caused a lot of activists to be angry at the fact that they are selling in such limited quantities. Listing a study does not mean it has been evaluated by the U. There were higher CD4 cell counts and less viral load in patients assigned to the three-drug group, proving that a three-drug treatment is more efficient than a two-drug one. Keep this medication in the container it came in, tightly closed, and out of reach of children. They were able to show that indinavir, when used with two other anti-HIV drugs, could significantly reduce the HIV viral load. DHHS Guidelines. Bilirubin levels often return to normal after a few months, but they should be monitored.

Agree: Indinavir

LEVITRA PACK-60 Call your Indinavir for medical advice about side effects. Key Drug Interactions For complete information on indinavir-related drug interactions, see the Drug Interactions section in the Indinavir Crixivan Prescribing Information. The content in this presentation are those of the author s and do not necessarily represent the official views of, nor an endorsement, by HRSA, HHS, or the U. If the intestinal tract plays a significant role in the presystemic clearance of rifabutin, the inhibitory activity of indinavir on rifabutin could depend on either luminal concentrations of indinavir, systematic concentrations of indinavir, or both. Several regimens containing indinavir in combination with nonnucleoside reverse transcriptase inhibitors also have been found to be effective, although adjustment in the indinavir dosage is required. This study seeks to examine if staggering the doses will make the 2 drugs more effective. Crixivan indinavir. The purpose of this study is to evaluate the safety of giving indinavir and rifabutin at the same time simultaneously vs 4 hours apart staggered to HIV-positive and HIV-negative adults. US : C Risk not ruled out.
SOFT PACK-40 Brand Viagra Bottled
GENERIC TESTPACK XXL-VCL 782
After cleavage the immature virus proteins are assembled into particles which bud from the cell as mature, infectious virons. Furthermore, it is no Indinavir recommended to use in the United States for initial treatments due to pill burden and risk of kidney stones. Indinavir interferes with an enzyme called protease, which is used by HIV-infected cells to make new viruses. Symptoms of ketoacidosis include dry mouth, nausea and vomiting, shortness of breath, breath that smells fruity, and decreased consciousness. Indinavir is a type of anti-HIV drug called a protease inhibitor. Retrieved This study took a look at clinical efficiency of the different treatments. If you have new or worsening symptoms at any time during your treatment with indinavir, be sure to tell your doctor. In Januaryresearchers synthesized indinavir sulfate Crixivanwhich was assigned compound number L, Drug Summary Indinavir, a protease inhibitor, is no longer used as part of antiretroviral therapy because of toxicity concerns. Under the following conditions, your need for water also increases: in hot weather when dancing or exercising if you have diarrhea if you have been vomiting Of course, if you have persistent diarrhea or vomiting, you should contact your doctor. Activists protested against this price because it made it harder for people to have access to the drug. Delavirdine, itraconazole, or ketoconazole: mg every 8 hours. The subunits of come together to form a catalytic tunnel capable of binding the nascent peptides and cleaving them into their mature form. References 1. Resistance mutations selected by indinavir frequently confer or contribute to resistance against other protease inhibitors. Nevertheless, indinavir remains a key antiretroviral drug in the market. When the activity of these enzymes is reduced the production of HIV slows. Indinavir interacts with a IIndinavir of antiretroviral medications, including Idninavir protease inhibitors, nIdinavir, and nevirapine; see Database of Antiretroviral Drug Interactions for information on recommended Indinqvir adjustments for the interaction of indinavir Indinafir other antiretrovirals. These changes Indinavi called mutations Indinavir can cause HIV to resist the effects of anti-HIV drugs, which means those drugs will no longer work for you. Do not stop taking indinavir without talking to your doctor. Phase 1. Resistance and cross-resistance Over time, as new copies of HIV are made in the body, the virus changes its structure. Combinations such as this are called antiretroviral therapy, or ART. Interactions with Other Drugs Indinavir is an inhibitor of cytochrome P 3A4 CYP3A4and may alter serum concentrations of other drugs metabolized by this pathway, including certain benzodiazepines, cholesterol-lowering agents, ergot derivatives, rifampin, phosphodiesterase type 5 PDE5 inhibitors sildenafil, tadalafil, or vardenafiland others. It was also estimated that the disease was responsible for the death of 2. Pharmacotherapy ;23 7 Production of this Web site has been made possible through a financial contribution from the Public Health Agency of Canada. You should be aware that alcohol and caffeine can dehydrate your body. The influence of efavirenz on the pharmacokinetics of a twice-daily combination of indinavir and low-dose ritonavir in healthy volunteers. Assessing the cascade of care for opioid use disorder in British Columbia. Some features of the lipodystrophy syndrome include:. How should indinavir be stored? Genetic research has shown that HIV originated in west-central Africa in the late 19th or early 20th century. Results may be different when indinavir is taken in combination with other PIs, such as ritonavir. For instance, some people may experience fat wasting, others fat gain, and others may experience both fat gain and wasting. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Combining indinavir with at least two other anti-HIV drugs delays the development of drug resistance. What side effects can indinavir cause? Indinavir should be used during pregnancy only if the potential benefits outweigh the risks. If you also take didanosine, take it on an empty stomach 1 hour before or 1 hour after you take indinavir. Commercially sold indinavir is indinavir anhydrous, which is indinavir with an additional amine in the hydroxyethylene backbone. Boyd M. Continue to take indinavir even if you feel well. There are restrictions on what sorts of food may be eaten concurrently with the unboosted indinavir treatment. Symptoms may occur weeks or months after you start treatment with indinavir. Journal of Acquired Immune Deficiency Syndromes ;32 2 Have a medical condition, or problems with use of alcohol or drugs, which would keep you from completing the study. These symptoms are sometimes referred to as ectodermal dysplasia. When indinavir is used as the only protease inhibitor in a regimen, for best absorption, this drug should be taken with water on an empty stomach, that is, either one hour before or two hours after a meal. ACTG is the first formal study of the pharmacokinetics of this dosing combination regimen in HIV seropositive patients. Agree to practice abstinence or to use birth control during the study. Traditional risk factors have a big impact on bone thinning in HIV-positive people. TruvadatenofovirlamivudineabacavirAtriplaStribildIndinavirEpzicom. Keep this medication in the container it Indianvir in, tightly closed, and out of reach of children. Abstract Implications of resistance to other antiretrovirals for indinavir treatment Indinavur to indinavir may be diminished by resistance to other Indlnavir inhibitors. Although the risk of developing diabetes is generally low, symptoms that may be related to diabetes increased thirst, increased urination, unexplained weight loss, fatigue and dry, itchy skin should be discussed with your doctor. Do not take this medicine in larger or smaller amounts or for longer than recommended. This list is not complete and many other drugs can interact with indinavir. CATIE ensures that these resources, developed to help prevent the transmission of HIV, hepatitis C and other infections, are written and reviewed by health experts for content accuracy. Some researchers suggest higher amounts of these liquids — up to 2. Indinavir is no longer recommended as a component of any antiretroviral therapy regimen and patients taking indinavir should switch to a safer and currently recommended antiretroviral agent. John's wort. Assessing the cascade of care for opioid use disorder in British Columbia. Be sure to tell your doctor how you are feeling during your treatment with indinavir. See also: Indinavir drug interactions in more detail. Drink at least 6 glasses of water each day to prevent kidney stones while you are taking indinavir. Indinavir is an inhibitor of cytochrome P 3A4 CYP3A4and may alter serum concentrations of other drugs metabolized by this pathway, including certain benzodiazepines, cholesterol-lowering agents, ergot derivatives, rifampin, phosphodiesterase type 5 PDE5 inhibitors sildenafil, tadalafil, or vardenafiland others. They sold it to Stadtalnder's Pharmacy and limited quantities to Veteran Administration's hospitals and some managed-care organizations. Information on drug interactions should be consulted, as dosage adjustments are frequently required, and some combinations are clearly contraindicated. There were higher CD4 cell counts and less viral load in patients assigned to the three-drug group, proving that a three-drug treatment is more efficient than a two-drug one. Symptoms may occur weeks or months after you start treatment with indinavir. Loss of fat from the legs, arms, and face can also happen. The end point of the study was death of development of opportunistic infections. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: rash hives itching peeling or blistering skin back pain pain in the side of your body middle to lower stomach pain blood in urine muscle pain or weakness nausea excessive tiredness unusual bleeding or bruising loss of appetite pain in the upper right part of your stomach flu-like symptoms dark yellow or brown urine yellowing of the skin or eyes shortness of breath fast heartbeat confusion dizziness headache paleness Indinavir may cause other side effects. Eligibility Criteria. Study Type :. It is usually taken every 8 hours three times a day. It was synthetically produced for the purpose of inhibiting the protease in the HIV virus. The information on this page is no longer maintained by AIDS info. Similarly, the response to indinavir is often diminished following virologic Indinaviir on a regimen containing another protease inhibitor see "Resistance". Furthermore, Invinavir drug has to be taken consistently or else users face dangers, meaning that the company has to take into account refills for users who take the drugs. There are multiple mechanisms of resistance. Clinical Trials Arena is using cookies We use them to give you the best experience. Talk to your doctor about the possible risks of using this drug for your condition. Changes in body fat including gain or loss of fat. If you have diabetes. Search for terms x. With the addition of indinavir, Ranbaxy now has 19 antiretrovirals on the overall WHO pre-qualification list. Results may be different when indinavir is taken in combination with other PIs, such as ritonavir. Activists protested against this price because it made it harder for people to have access to the drug. Management of nephrolithiasis may require temporary discontinuation of indinavir for one to three days or permanent discontinuation. Nelfinavir: mg twice daily. Alphabetical fact sheet listing Categorized Indinavie sheet listing. Indinavir and other protease inhibitors Some specialists prescribe indinavir in combination of with Indinavir protease inhibitor called ritonavir Norvir. There may be other combinations of protease inhibitors that can be prescribed together with indinavir. Lipodystrophy Indinavie The HIV lipodystrophy syndrome is the name given to a range of symptoms that can develop over time when people use ART. To reduce the risk of developing kidney stones, people using indinavir should drink at least 1. September Patients had to have CD4 cell counts less than and at least 3 months of AZT therapy before the trials. Because of the complex regimens and side effects associated with the use of indinavir, this drug is rarely used in Canada and other high-income countries. They were able to show that indinavir, when used with two other anti-HIV drugs, could significantly reduce the HIV viral load. Journal of Acquired Immune Deficiency Syndromes ;32 2
Common use

Indinavir is used to treat HIV infection in some patients when used in combination with certain other medicines. It is an HIV protease inhibitor. It works by slowing the growth of HIV, the virus that causes AIDS.



Dosage and directions

Take Indinavir by mouth on an empty stomach at least 1 hour before or 2 hours after eating. You may also take it with a light meal that is low in calories, fat, and protein. Take Indinavir with water. You may also take it with other liquids such as skim milk, juice, coffee, or tea. It is recommended to drink extra fluids.



Precautions

Before using Indinavir discuss with your doctor if you are pregnant, planning become pregnant or breast-feeding, if you have allergy to food, medicines, or other substances, if you are taking any prescribed or not prescribed medications, herbal products, or dietary supplements, have cirrhosis, liver or kidney problems, diabetes, high blood sugar, high cholesterol, kidney stones, urinary problems (white blood cells in the urine), or blood problems (hemophilia hemolytic anemia).



Contraindications

Do not use Indinavir if you are allergic to its components; you are taking alfuzosin, amiodarone, astemizole, atazanavir, certain benzodiazepines (eg, alprazolam, oral midazolam, triazolam), cisapride, conivaptan, an ergot alkaloid (eg, ergonovine, ergotamine), erythromycin, certain HMG-CoA reductase inhibitors (lovastatin, rosuvastatin, simvastatin), pimozide, a proton pump inhibitor (omeprazole), ranolazine, rifampin, salmeterol, a serotonin 5-HT1 receptor antagonist (eg, eletriptan, sumatriptan), St. John's wort, or terfenadine, sildenafil for pulmonary arterial hypertension (PAH).



Possible side effect

The common side effects are bad taste in the mouth; diarrhea; dizziness; drowsiness; headache; nausea; tiredness; vomiting; weakness. Seek urgent medical attention if you experience the following severe side effects: allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back, flank, or side pain; bloody or cloudy urine; change in the amount of urine; changes in appetite; chest pain; chills; confusion; dark urine; fast or irregular heartbeat; fever; flushed face; heartburn; ingrown toenails; joint or muscle aches; mental or mood changes; numbness of the mouth; one-sided numbness or weakness; pain while urinating; pale stools; red, swollen, or blistered skin; severe dizziness or fainting; severe or persistent stomach pain or upset; speech problems; swelling of the feet, hands, lower legs, or stomach; unusual hair loss; unusual paleness; unusual tiredness; unusually dry skin; vision changes; weight changes; yellowing of the skin or eyes.



Drug interaction

Tell your doctor if you are taking any drugs especially about the following: amiodarone, astemizole, certain benzodiazepines (alprazolam, midazolam,triazolam), cisapride, ergot alkaloids (ergotamine), erythromycin, pimozide, salmeterol, or terfenadine; alfuzosin, conivaptan, certain HMG-CoA reductase inhibitors (atorvastatin, lovastatin, rosuvastatin, simvastatin), ranolazine, serotonin 5-HT1 receptor antagonists (eletriptan, sumatriptan), or sildenafil (for PAH); atazanavir; proton pump inhibitors (eg, omeprazole), rifampin, or St. John's wort.



Missed dose

If you miss a dose of Indinavir by more than 2 hours, do not take that dose. Take your next dose as scheduled. If you miss the dose by less than 2 hours, take that dose immediately and then return to your regular dosing schedule. It is important not to miss doses of Indinavir. Do not take 2 doses at once.



Overdose

If you thin that overdosed Indinavir seek urgent medical help. Overdose symptoms are blood in the urine; diarrhea; lower back pain; nausea; vomiting.



Storage

Store Indinavir at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in the original bottle. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Indinavir out of the reach of children and away from pets.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.