Generic Prograf (Tacrolimus)
Prograf
Prograf suppresses immune system of the body to avoid rejection of a transplanted heart, liver, or kidney.
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Product Description
This medicine may increase Prograf risk of getting skin cancer or cancer Prrograf the lymph system lymphoma. Starting total daily dose of 0. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Arms and Interventions. The patient population in Spence et al. Dosages are titrated to target blood levels. Do not take more or less Proraf it and do not take it more often than your doctor ordered. If you experience any of the following symptoms, call your doctor immediately: sore throat; cough; fever; extreme tiredness; flu-like symptoms; warm, red, or painful skin; or other signs of infection. Potential savings from substituting generic drugs for brand-name drugs: Medical expenditure panel survey, — Place 1 to 2 tablespoons 15 to 30 milliliters of water into a cup containing the granules. We did not evaluate the most important factor that drives generic substitution—cost savings. Accessed April 3, After the cyclization, the pre-tacrolimus molecule goes through the post-synthase tailoring steps such as oxidation and S -adenosyl methionine. However, there is a lack of consistent evidence as to whether dosing based on rs genotype results in improved clinical outcomes such as a decreased risk for transplant rejection or drug toxicitieslikely because patients taking tacrolimus are subject to therapeutic drug monitoring. Transplantation: July - Volume - Issue - p S Clinical Pharmacokinetics. Avoid being near people who are sick while you are using this medicine. When applied locally on eczema, tacrolimus has little to no bioavailability. Veterinary Ophthalmology. Tacrolimus belongs to a group of medicines known as Prograf agents. Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. Call your doctor right away if you have any signs of infection such as fever, chills, flu symptoms, cough, sweating, painful skin sores, skin warmth or redness, or muscle aches. This is typically accomplished through a small-scale in vivo study of healthy volunteers. It is applied on the active lesions until they heal off, but may also be used continuously in low doses twice a weekand applied to the thinner skin over the face and eyelids. Prograf dosage information in more detail. Practitioners believed that Prograf and Advagraf were completely interchangeable, dose for dose. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Please review our privacy policy. This effect has been seen most commonly in people who are Hispanic or African-American. Trough levels are obtained once monthly for stable kidney transplant patients. Toggle navigation. Learn more about other Liver Transplant Drugs. Tacrolimus has Prograaf Prograf to reduce the risk of serious infection in lupus nephritis, when Progra to other agents. As Prkgraf ointmentProgrqf is used in the treatment of eczemain particular atopic dermatitis. The following attributes may increase the potential for a mix-up between Prograf and Advagraf: the 2 formulations contain the same generic medication tacrolimus ; both medications are indicated for use after organ transplantation; both are available in a capsule format, for oral use, in the same dosage strengths 0. Wear protective clothing and use sunscreen SPF 30 or higher when you are outdoors. Eligible kidney-pancreas recipients will be recruited and after obtaining informed consent, randomized to continue their current total daily Prograf dosage or switch to the equivalent once daily dose of Advagraf. In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region. See also: Prograf drug interactions in more detail. Taxonomy of the producing strain". See also: Prograf side effects in more detail. Keep a Progrqf of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine. I accept the Terms and Privacy Policy. At time of conversion, the mean age of recipients was Only physicians experienced in immunosuppressive therapy should prescribe Prograf. Boxed Warning: Malignancies. Here we found that a 7-day exposure of male B. Risk rPograf new onset diabetes after transplant esp. Interactive image. Talk with your doctor and family members or friends about deciding to join a study. Renal or hepatic impairment: use lowest effective dose. Annu Rev Fish Dis — Eligible kidney-pancreas recipients will be recruited and after obtaining informed consent, randomized to continue their current total daily Prograf dosage or switch to the equivalent once daily dose of Advagraf. Fermentation, isolation, and physico-chemical and biological characteristics". An Existing Folder. Subscribe to our newsletters. Detailed Description:. Study Start Date :. Live vaccines include measles, mumps, rubella MMRrotavirus, typhoid, yellow fever, varicella chickenpoxzoster shinglesand nasal flu influenza vaccine. Increased risk of infection. Grapefruit may interact with tacrolimus and lead to unwanted side effects.
Common use

Prograf suppresses immune system and is used to prevent organ rejection after transplantation of heart, kidney, small bowel, bone marrow. Its active component is anhydrous tacrolimus. The drug binds to cytosolic protein (FKBP 12) and inhibits calcineurin hereby suppressing T-cell dependent immune response of the organism, formation of cytotoxic lymphocytes, proliferation of B cells depending on T-helpers, and formation of interleukin-2, -3 and Оі-interferon.



Dosage and direction

The daily dose of Prograf should be divided in two intakes separated by twelve hours. The capsules should be taken immediately after taking them out from the blister packs with full glass of water on an empty stomach, or at least one hour before or 2-3 hours after a meal. Fatty food decreases absorption of the medication. Correction of the dose is needed inpatients with serious liver impairment.



Precautions

Risk of caner and especially skin cancer and infectious diseases increases due to immune suppressing effect of Prograf. Avoid exposing yourself to direct sun rays. Blood cell count, kidney and liver unction should be monitored on a regular basis while taking this medication. Diabetes may develop especially in Hispanic or African-American patients. Do not take the medicine with a grapefruit juice. This medication can appear in breast milk and transfer through placenta which can be harmful to a baby. Breastfeeding should be stopped while on Prograf. Inform your doctor if you have kidney or liver diseases, high blood pressure, or if you have taken cyclosporine (Neoral, Sandimmune, Gengraf) within the day before.



Contraindications

The preparation cannot be administered in patients hypersensitive to tacrolimus, other macrolides, or or hydrogenated castor oil.



Possible side effect

Side effects of Prograf are numerous and include arterial hypertension, hypotension, angina, stroke, tachycardia, arrhythmia, diarrhea, nausea, vomiting, abdominal pain, change of liver transaminases activity, constipation, anemia, easy bruising and bleeding, changes in clotting, kidney disorders and failure, hyperglycemia, hyperpotessemia, diabetes, seizures, pain in joints, miastenia, tremor, headache, vision changes, dizziness, depression, mental confusion, hallucinations, difficulty breathing, allergy, achne, photosensitivity, high risk of tumor formation, high body temperature, swelling of extremities, baldness. In case of bothersome and serious side effects seek immediate medical attention.



Drug interaction

Prograf may slow down metabolism of Cyclosporine (Neoral, Sandimmune, Gengraf) thus increasing its toxicity. As Prograf is metabolized by cytochrome CYP 3A4, a concomitant use of medications affecting or being metabolized by this cytochrome may change Prograf levels in the blood (for example testosterone, cortisone). Tacrolimus binds to proteins of blood serum and and may change (mutually) effects of the medications with high affinity to serum proteins such as peroral anticoagulants, diabetic drugs or NSAIDs. Concomitant use of Prograf with neurotoxic or nephrotoxic medication may increase toxicity (aminoglycosides, inhibitors of DNA gyrase, vancomycin, co-trimoxazole, NSAIDs, ganciclovir or acyclovir). Avoid co-administration of Prograf with potassium-saving diuretics of medicines which contain potassium to avoid hyperpotassemia (Dyazide, Maxzide, amiloride, Moduretic, and spironolactone, Aldactone). Effects of vaccination may be decreased and use of live attenuated vaccines should be avoided. Inform your doctor about all drugs and herbal products you are taking.



Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.



Overdose

In cases of accidental Prograf overdose the following symptoms were described: tremor, headache, nausea, vomiting, infection, rash, lethargy, increased urea nitrogen in blood and increased serum concentrations of creatinine and alanine transaminase (ALT).



Storage

Prograf should be stored at room temperature between 15-30 C (59-86 F).



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.