Generic Provigil (Modafinil)
Provigil
Provigil is a wakefulness-promoting agent for adults who experience excessive sleepiness.
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Product Description
Side effects and contraindications. Stop taking this medicine and get emergency medical help if you Provigil a skin rash or hives, blisters or peeling, mouth sores, trouble breathing or swallowing, fever, swelling in your legs, dark urine, yellowing of your skin or eyes, or swelling in your face. Studies show that Provigil increases the ability to stay awake compared to a placebo in people with narcolepsy, sleep apnea, or shift work sleep disorder. If you have any questions about this medicine ask your pharmacist. Provigil side effects. Also Read Armodafinil vs. If you think you may have a medical emergency, immediately call your physician or dial Here are some of them. Journal of Medicinal Chemistry. Prescriber's Guide: Stahl's Essential Psychopharmacology 6th ed. January 3, European Journal of Pharmacology. Teva will also grant non-exclusive U. Oxford University Press. IUPAC name 2-[ diphenylmethyl sulfinyl]acetamide. Archived from the original on November 25, Provigil reviews. Because of the risk for development of skin or hypersensitivity reactions and serious adverse psychiatric reactions, the European Medicines Agency has recommended that new patient prescriptions should be only to treat sleepiness associated with narcolepsy. Although not common, some people may also experience feelings of euphoria. There is the lobbyist, who wakes up at 5 a. Outcome Measures. Enrollment :. You should not use Provigil if you have ever had an allergic reaction or skin rash while taking modafinil or armodafinil Nuvigil. If you have a sleeping disorder, these are the best places online for information, support, and advice. Take Provigil exactly as prescribed by your doctor. From Wikipedia, the free encyclopedia. It is important for patients to take Provigil under the supervision of a licensed physician who knows their medical history and has record of other medications that they are taking. Shift work sleep disorder occurs in individuals who work nontraditional hours like split shift, graveyard shifts, or rotating shifts. Drinking certain fruit juices, such as grapefruit juice and orange juice, while taking Provigil might change how your body handles the drug. Others: A Amoxapine Antihistamines e. Journal of Affective Disorders. Rising incidence and persistently extravagant mortality of hospitalized pneumonia: a year population-based study in Denmark. Provigil modafinil is a medication that promotes wakefulness.

Provigil - congratulate, what

Provihil Inc. There are no factors that are known to predict the risk of occurrence or the severity of multi-organ hypersensitivity reactions. Retrieved July 4, On December 24,anticipating the expiration of exclusive marketing rights, generic drug manufacturers Mylan, Teva, Barr, and Ranbaxy applied to the FDA to market a generic form of modafinil. Now they take them to get higher grades". Thereafter cells were washed and medium exchanged not later than RPMI medium containing ciprofloxacin to butcher any Provigil bacteria. The criteria include either: 1 excessive sleepiness or insomnia, plus frequent episodes of impaired breathing during sleep, and associated features such as loud snoring, morning headaches and dry mouth upon awakening; or 2 excessive sleepiness or insomnia and polysomnography demonstrating one of the following: more than five obstructive apneas, each greater than 10 seconds in duration, per hour of sleep and one or more of the following: frequent arousals from sleep associated with the apneas, bradytachycardia, and arterial oxygen desaturation in association with the apneas. Skip the missed dose if it is almost bedtime. DS participated in the devise of the study and coordinated it. In vitro data also demonstrated that modafinil produced an apparent concentration-related suppression of expression of CYP2C9 activity. All patients met the criteria for chronic SWD. Concomitant administration of armodafinil with quetiapine reduced the systemic exposure of quetiapine. Pregnancy: Based on animal data, may cause fetal harm. Side effects. Cyclosporine - One case of an interaction between modafinil and cyclosporine, a substrate of CYP3A4, has been reported in a 41 year old woman who had undergone an organ transplant. However, the wake-promoting effects of modafinil, unlike those of amphetamine, were not antagonized by the dopamine receptor antagonist haloperidol in rats. Continuing Previously Prescribed Treatments Inform patients that it may be critical that they continue to take their previously prescribed treatments e. Herbal teas are popular beverage choices when it comes time to relax and unwind. For each test session, the subject was told to lie quietly and attempt to sleep. And then there is the brain researcher who can find connections no one else is seeing. You should not use Provigil if you have ever had an allergic reaction or skin rash while taking modafinil or armodafinil Nuvigil. Advise patients to notify their physician if they become pregnant or intend to become pregnant during therapy. Reports of serious dermatologic adverse effects and psychiatric events has resulted in the FDA's Pediatric Advisory Committee unanimously recommending that a specific warning against the use of modafinil in children be added to the manufacturer's labeling; use only if first- and second-line treatments have failed and the benefits outweigh the risks. Provigil is a schedule IV controlled substance that carries risk for abuse and dependence. It should be noted that not all patients with a complaint of sleepiness who are also engaged in shift work meet the criteria for the diagnosis of SWD. This leads to daytime sleepiness. Cell surface associated glycohydrolases in normal and Gaucher disease fibroblasts. In the United States military, modafinil has been approved for use on certain Provigkl Force missions, and it is being investigated Porvigil other uses. Pgovigil has been used off-label in trials with people with symptoms of post-chemotherapy cognitive impairmentalso known as "chemobrain", but a review found that it was no better than placebo. I'd like to be fully alert, fully focused, and fully present all the time" Asprey said. What Is Biphasic Sleep? Retrieved December 4, The Journal of Pharmacology and Experimental Therapeutics. About About Drugs. For obstructive sleep apnea, it is recommended that continuous positive airway pressure be appropriately used before considering starting modafinil to help with daytime sleepiness. World News Tonight. Views Read Edit View history.

Common use

Provigil it is used to improve wakefulness in patients with excessive sleepiness caused by narcolepsy, sleep apnea, or shift work sleep disorder. The Provigil effects are similar to caffeine. The mechanism of their work consists in promotion of wakefulness by stimulating the brain via affecting neurotransmitters.



Dosage and direction

Take this medication exactly as prescribed. Treatment usually continues for twelve weeks or less. Provigil is usually given in mornings to prevent daytime sleepiness. You may also take it one hour before the start of a work shift if you are treated for shift work sleep disorder. Provigil may be used together with a continuous positive airway pressure (CPAP) machine, the mechanism which helps people with obstructive sleep apnea to pump pressurized air into the nose while sleeping.



Precautions

Notify your doctor if you suffer from angina (chest pain), a heart problem, liver or kidney disease, cirrhosis, a heart muscle or valve disorder (mitral valve prolapse), drug addiction in history, if you are treated by blood pressure medication, or if you have recently had a heart attack. This medication may affect thinking reactions, be cautious while driving, operating machinery or performing any potentially hazardous activities. If you experience any kind of skin rush inform your doctor about it immediately. This may be a sign of a serious condition which may require hospitalization. The symptom usually occurs within 1 to 5 weeks after the first dose. Inform your doctor if you are breastfeeding or pregnant.



Contraindication

This medication is contraindicated in the patients with allergy to modafinil or armodafanil (Nuvigil).



Possible side effects

Besides allergic reaction such as hives, rash, facial swelling and difficulty breathing the following adverse reactions may occur vomiting with a severe blistering, fever, sore throat, headache, peeling, numbness, pain, muscle weakness, bruising, severe tingling, white sores on the mouth or lips, easy bruising or bleeding, unusual thoughts or behavior, hallucinations, anxiety, depression, uneven heart beats, chest pain. Inform your doctor immediately if theses symptoms aggravate and become bothersome.



Drug interaction

Methylphenidate and dextroamphetamine may decrease absorption of Provigil. Provigil is able to increase blood levels of clomipramine. Effectiveness of Provigil may be diminished by cyclosporine (Sandimmune), theophylline, and hormonal contraceptives. Inform your doctor about all prescribed and over-the-counter medications and herbal products you are using and especially about propranolol (Inderal), rifampin (Rifadin, Rimactane, Rifater), midazolam (Versed), diazepam (Valium), or triazolam (Halcion), itraconazole (Sporanox) or ketoconazole (Nizoral), doxepin (Sinequan), imipramine (Tofranil, Janimine), amitriptyline (Elavil, Etrafon), nortriptyline (Pamelor), phenytoin (Dilantin), phenobarbital (Luminal, Solfoton), carbamazepine (Carbatrol, Tegretol), MAO inhibitors rasagiline (Azilect), selegiline (Eldepryl, Emsam), isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil).



Missed dose

Take the missed dose as soon as you remember unless you do not plan to stay awake for several hours. Return to your regular scheme. Do not take the drug if it is almost your bedtime. Do take more than one dose of this medication at once.



Overdose

Overdose symptoms include confusion, trouble sleeping, feeling excited or agitated, nausea, or diarrhea. Contact your doctor immediately if you suspect overdose.



Storage

Store Provigil at room temperature, between 59-86 F (15-30 C) in a tight dark container. Save from heat, moisture, and sunlight.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.