Generic Rebetol (Ribavirin)
Rebetol is used in combination with interferon drugs Intron A or PEG-Intron to treat chronic hepatitis C.
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Product Description
Ribavirin is an anti-HCV agent [see Microbiology Adult Treatment. This U. Male patients and their female partners should use effective contraception during treatment with REBETOL and for the 6-month post-therapy period [see Warnings and Precautions 5. Rat pups dosed from postnatal Days 7 through 63 demonstrated a minor, dose-related decrease in overall growth at all doses, which was subsequently manifested as slight decreases in body weight, crown-rump length, and bone length. If you need to take ribavirin, the side effects can be difficult. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Ribavirin has been shown in cell culture to inhibit phosphorylation of lamivudine, stavudine, and zidovudine, which could lead to decreased antiretroviral activity. Clinical Trials Research. Regardless of treatment group, SVR rates were lower in subjects with poor prognostic factors. The anemia may also cause or worsen cardiac conditions. Legislative History. Because guanosine triphosphate GTP plays a critical role in the viral genome replication process, inhibition of IMPDH would result in the prevention of viral replication. Before you take REBETOL, tell your healthcare provider if you have or ever had: treatment for hepatitis C that did not work for you breathing problems. For all genotypes, higher fibrosis scores were associated with a decreased likelihood of achieving SVR. Adverse Effects Two potentially serious ribavivirn-associated adverse effects are listed as black box warnings. Special Populations: Renal Dysfunction The pharmacokinetics of ribavirin were assessed after administration of a single oral dose mg of ribavirin to non-HCV-infected subjects with varying degrees of renal dysfunction. DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. These are not all the possible side effects of Rebetol. Contributing to Cancer Research. P-INFa-2b and 2. I accept the Terms and Privacy Policy. Available for Android and iOS devices. Rebetol on its own has no effect on eliminating the hepatitis-C virus from the body. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. The increased AUC tf appears to be due to reduction of renal and nonrenal clearance in these subjects. Take the missed dose on the same day you remember it. Ribavirin and its triazole carboxamide and triazole carboxylic acid metabolites are excreted renally. See also: Rebetol side effects in more detail. Inits first major use was the treatment of RSV respiratory syncitial virus infections in pediatric patients, but since its FDA approval init has primarily been used as a component in treating Hepatitis C by inhibiting the synthesis of viral RNA. If a pregnancy occurs, your name may be listed on a pregnancy registry to track the effects of ribavirin on the baby. Evaluate for ophthalmologic disorders.

Refuse: Rebetol

Lanoxin Maintain adequate hydration. Funded by a grant from the. Showing results with Videos. If you become anemic Rebbetol on ribavirin, your medical provider may need to adjust the dose accordingly. No Duty to Update The information contained in this website was current as of the date presented. Currently, still plays a role on a limited basis in combination with some direct-acting antiviral agents and combinations.
Fosamax Brush your teeth well 2 times each day. Depending upon the manufacturer, tablets are available in mg, mg, mg, and mg. Impairment of Fertility. Tell your healthcare provider if you have ever had any heart problems. The limited distribution of P-INFa-2a results in a longer half-life. These are not all the possible side effects of Rebetol.
DOXYCYCLINE This would result in reduced capacity for viral replication within an infected cell. If needed, 2 nd dose reduction of PegIntron is to 0. The primary toxicity of ribavirin is hemolytic anemia. Ribavirin may be added to direct-acting antiviral DAA therapy in people that have severe hepatic impairment decompensated cirrhosis or in people who have certain resistance mutations that make the DAA less effective. Journal of Medicinal Chemistry. Weight and height gain of pediatric subjects treated with PegIntron plus REBETOL lagged behind that predicted by normative population data for the entire length of treatment. Advise females of reproductive potential that they must have a pregnancy test prior to initiating treatment and periodically during therapy.
Use this Search to quickly find items or navigate the site. Use the arrow keys to move through the suggestions. To select a suggestion, hit the enter key. Take missed dose as soon as possible, unless it is closer to the time of your next dose. Archived PDF from the original on 3 November The anemia may also cause or worsen cardiac conditions. Rebetol Usage Back to Top. Individuals with a history of significant or unstable heart disease should not use Rebetol capsules, as fatal and non-fatal heart attacks have occurred in patients with anemia caused by the drug. Additional Information For additional information on Rebetol capsules, Rebetron Combination Therapy and other company products, please visit Schering-Plough. What benefit has Rebetol shown during the studies? It previously played a major part in HCV treatment for years when used in combination with interferon but is not generally reserved for certain patient populations with severe hepatic impairment. Risk Factors. Current Congress. Resources for Trainees. Related Brands. Vartanian J ed. No Duty to Update The information contained in this website was current as of the date presented. Retrieved 16 April Cancer Diagnosis Research. Follow the directions on your prescription label carefully. Call your doctor for medical advice Rebetol side effects. Legal Requirements. TGA eBusiness Services. It is unknown if ribavirin passes through breast milk or the impact it could have on breastfeeding babies. Take this medication exactly as prescribed by your doctor. Subscribe to Drugs. Cancer Screening Overview. Recent Public Laws. Archived PDF from the original on 13 December Such 5' imidazole riboside derivatives show antiviral activity with 5' hydrogen or halide, but the larger the substituent, the smaller the activity, and all proved less active than ribavirin. Retrieved 8 December Rebetol drug interactions in more detail. The first property is due to taribavirin's basic amidine group which inhibits drug entry into RBCs, and the second property is probably due to increased concentration of the enzymes which convert amidine to amide in liver tissue. Tell your doctor if you are pregnant or plan to become pregnant. You should not take Rebetol with didanosine. If there is any deterioration of cardiovascular status, therapy should be suspended or discontinued [see Dosage and Administration 2. Ask our expert. However, hepatic enzyme abnormalities, renal failure, hemorrhage, and myocardial infarction have been eRbetol with administration of single subcutaneous doses of INTRON A that exceed dosing recommendations. Clinical trials of Rebwtol combination therapy did not include sufficient numbers of subjects eRbetol 65 and Rebefol to determine if they respond differently eRbetol younger subjects. Use this Search to quickly find items or navigate the site. Advise patients to notify the physician immediately in the event of a pregnancy [see Contraindications 4Warnings and Precautions 5. Refer to Intron A labeling for interferon dosing information. These effects occurred at doses as low as one twentieth of the recommended human dose of ribavirin [see Boxed WarningContraindications 4and Use in Specific Populations 8. The anemia may also cause or worsen cardiac conditions. If severe adverse reactions or laboratory abnormalities develop during REBETOL combination therapy, modify or discontinue the dose until the adverse reaction abates or decreases in severity see Table 4 [see Warnings and Precautions 5 ]. It is freely soluble in water and slightly soluble in anhydrous alcohol. If you are a consumer or patient please visit this version. PegIntron in combination with ribavirin may cause severe decreases in neutrophil and platelet counts, and hematologic, endocrine e. Levels of Evidence: Treatment.
Common use

Main component of antiviral drug Rebetol is Ribavirin. It is used in combination with interferon drugs Intron A or PEG-Intron to treat chronic hepatitis C. Rebetol inhibits the replication of new virions, selectively inhibits synthesis of viral RNA, it does not suppress synthesis of RNA in a normal cells. Rebetol is the most effective against: herpes simplex virus, virus of smallpox, influenza viruses A and B, paramyxovirus (parainfluenza, mumps, Newcastle disease), reovirus, oncogenic RNA viruses.

Dosage and direction

Make sure you drink plenty of water while taking Rebetol, especially with your first intakes of the medication. Treatment continues for 24-48 weeks. To treat hepatitis C take Rebetol orally with food and full glass of water. Do not chew the tablet, swallow it whole. Recommended dose of Rebetol is 1-1.2 g a day divided in two for morning and evening intakes.


Rebetol is may cause a significant risk of serious harm to developing infants and abnormalities in a man's sperm, be very attentive using contraception medications. At least two forms of birth control during treatment and for six months afterwards are required.


Rebetol is contraindicated in patients hypersensitive to the components of Rebetol, in pregnant and breastfeedign women, in patients with chronic heart failure, myocardial infarction, kidney or liver failure, severe anemia, decompensated cirrhosis, autoimmune diseases, incurable thyroid disease, severe depression with suicidal intentions, children and adolescents under 18. Cautiousness should be exercised in patients with decompensated diabetes mellitus, pulmonary embolism, heart failure, thyroid disease (including hyperthyroidism), impaired clotting, thrombophlebitis, myelosuppression, haemoglobinopathy (thalassemia, sickle cell anemia), depression, suicidality (also in history).

Possible side effect

The most serious adverse reaction to Rebetol is anemia. Other side effects include: blood disorders, fever, hair loss, depression, fatigue, headache, insomnia, irritability, nausea, shortness of breath, joint or muscle pain, weight loss. Notify your doctor immediately if you experience any serious manifestation of the side effects listed above.

Drug interaction

Concomitant use with other antiviral drugs such as zidovudine (Retrovir), zalcitabine (Hivid) or stavudine (Zerit), may cause lactic acidosis. Medications which contain Mg2+ Г‰ Al3+, and also simethicone decrease absorption of Retrovir. Retrovir suppresses effects of zidovudine. In the patients with HIV infection concomitant treatment with Retrovir, zidovudine and stavudine leads to HIV viremia (a condition where viruses get into the bloodstream and can affect the rest of the body) and requires change of treatment.

Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.


If you suppose that took too much of this medication seek immediate medical attention. There is no information about adverse effects of Rebetol overdose.


Rebetol should be stored at room temperature between 2-8 C (36-46 F).


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.