Generic Clozaril (Clozapine)
Clozaril
Clozaril is an atypical antipsycotic. It is used to treat schizophrenia in patients who do not respond to other medicines.
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Product Description

Clozaril - can

Analysis of safety databases suggests that the use Clozarul clozapine is associated with an increased risk of myocarditis especially during, but not limited to, the first month of therapy. The tablets are available in Clozaril strengths: 25 mg tablets: yellow flat circular tablets coded CLOZ 25 on one side and with a breakline on the other. Clozapine is a dibenzodiazepine that is structurally related to loxapine. Place the open tip of the oral syringe into one side of your mouth. Journal of Chemical Information and Modeling. Antagonists: AR-A Beta blockers e. Clozaril is a medication known as an atypical antipsychotic that is used to treat symptoms of schizophrenia when standard medications have failed. Clozaril is not approved for the treatment Clozail patients with dementia-related psychosis. Clozapine is linked to urinary incontinence[40] though its appearance may be under-recognized. Dopamine receptor Clozsril. Retrieved 20 September The biggest disadvantages of Clozaril are the increased risk for lowered white blood cell count and seizures, and the other potential long-term side effects, which can include tardive Clozaril, hyperglycemia, and weight gain. Atypical antipsychotics may also increase the risk of cardiovascular side effects, diabetes, weight gain, and high cholesterol. What should I avoid while taking clozapine? Call your doctor right away if you have signs of infection such as: weakness, fever, swollen gums, sore throat, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing. What side effects can this medication cause? Place the cap back on the bottle and turn it clockwise to the right to tighten it. Avoiding stress over the festive season. Your doctor will probably want to decrease your dose gradually. The risk of this side effect is higher in women and older adults. SeroquelquetiapineAbilifyolanzapinerisperidonearipiprazole. Clozaril may enhance the effects of alcohol. Seek emergency medical attention or call the Poison Help line at A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines. Archived from the original on 10 November Before starting this medicine and during your therapy, checks will be required to monitor the levels of various components in your blood. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Push on the plunger so the medication goes back into the bottle and the air disappears. Clozaril carries five serious warningscalled black box warnings, about possible severe side effects and drug interactions. Dopamine receptor modulators. In addition to hyperglycemiasignificant weight gain is frequently experienced by patients treated with clozapine. What other information should I know? Partners and Accreditations This site complies with the HONcode standard for trustworthy health information: verify here. When discontinuing clozapine, gradual dose reduction is recommended to reduce the intensity of withdrawal effects. The tablets are available in 2 strengths: 25 mg tablets: yellow flat circular tablets coded CLOZ 25 on one side and with a breakline on the other. Do not take Clozaril after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering. Both your doctor and your pharmacist have to be registered with this program that the manufacturers created in order to prescribe and dispense your Clozaril. Clozapine is an antipsychotic medicine works by changing the actions of chemicals in the brain. The first test in humans in was considered a failure. Jump over to the doctors only platform. Caution with concomitant drugs known to prolong the QT interval eg, quinidine, procainamide, amiodarone, sotalolcertain antipsychotics eg, ziprasidone, iloperidone, chlorpromazine, thioridazine, mesoridazine, droperidol, pimozideantibiotics eg, gatifloxacin, moxifloxacin, sparfloxacinand others eg, pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol, tacrolimus. Do you or your family have a history of fits? In Decemberclozapine lCozaril approved in the US for reducing the risk of suicide in schizophrenic or schizoaffective patients judged to be at Clozarjl risk for suicidal behavior. In particular, tell your doctor if you are taking any of the following:. Skip to Content. The data suggest that clozapine may be more likely to cause adverse metabolic effects than some of the other atypical antipsychotics. Because of the risks associated with Clozaril, its use is limited to patients in whom therapy is indicated as set out in section 4. Also, if you accidentally skip two or more doses of Clozaril, talk to your doctor before taking your next dose as you may need to take a lower dose for a time. If you are not sure, ask your doctor or pharmacist. J Clin Psychiatry. By using this site, you agree to the Terms of Use and Privacy Policy. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Archived from the original on 22 January If you have a history of clotting you may be at increased risk of experiencing Clozaril clot-related problems such as heart attack, stroke, or clots in the deep veins of your leg. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. Clozapine belongs to a family of medications called antipsychotics. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with clozapine. This list is not complete and many other drugs can interact with clozapine. Archived from the original on 23 October Clozaril works by changing chemicals in the brain. Current Medical Research and Opinion. If you plan to have surgery, tell your doctor that you are taking Clozaril. Tightly close your lips around the oral syringe and push on the plunger slowly as the liquid goes into your mouth. Clozapinesold under the brand name Clozaril among others, [2] is an atypical antipsychotic medication. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach. Clozapine mg-MYL, green, round. Seizures have been associated with the use of clozapine. Tell your doctor if you experience any of the following symptoms:. Orthostatic hypotension, with or without syncope, can occur with clozapine treatment, especially when you first start taking it or your dose is changed. Take clozapine at around the same time s every day. Clozaril can increase the drowsiness caused by CClozaril that affect your nervous system. Clozaril Clozsril interactions in more detail. Talk to Clozrail doctor about drinking caffeinated beverages while taking this medicine. If you experience any of the Cloazril symptoms, call your doctor immediately: extreme tiredness; weakness; Closaril, sore throat, chills, or other signs of flu or infection; unusual vaginal discharge or itching; sores in your mouth or throat; wounds that take a long time to heal; pain or burning while urinating; sores or pain in or around your rectal area; or abdominal pain. Clozapine is not approved by the Food and Drug Administration FDA for the treatment of behavior problems in older adults with dementia. This list is not complete and many other drugs can interact with clozapine. It works by changing the activity of certain natural substances in the brain. Azacyclonol Cannabidiol Oxypertine Reserpine Tetrabenazine. It is also important information to carry with you in case of emergencies. Skip to main content Skip to footer. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at These symptoms can usually be prevented by getting up slowly and flexing leg muscles and toes to get the blood flowing. You can further our understanding of adverse events by reporting them to:. Clozaril slide 21 of 22, Clozaril. European Journal of Clinical Pharmacology. Schizophrenia is a mental illness that's characterized by disturbed thinking, unusual emotions, and hallucinations. Coozaril mg-TEV, yellow, oval. Pulmonary disease. Benkert O, Hippius H. Active Ingredients Flurazepam monohydrochloride. Incidence and risk factors in the United States". A review]". Published case reports have stated that the use of benzodiazepines and clozapine concomitantly can result in severe adverse reaction such as respiratory arrest, cardiac arrest and sudden death. However, when studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychoticsthe US Food and Cllzaril Administration FDA and health authorities in most other countries approved its use only for treatment-resistant schizophrenia, and required Restricted Distribution, a Patient Registry and regular C,ozaril monitoring to Cozaril granulocytopeniabefore agranulocytosis develops. Clozaril Images. Take Clozaril exactly as prescribed by your doctor. Serious and sometimes fatal infections may occur during treatment with clozapine. Subsequent dose increases can be in increments of up to mg once or twice weekly. Take the medication right after you draw it into the oral syringe. Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop. August You may need to stop using the medicine for a short time. Product subject to medical prescription which may not be renewed A. Click Here. Blood and lymphatic system disorders. United States Food and Drug Administration. Use in Older Adults: Studies have shown that older adults with dementia a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality who take antipsychotics medications for mental illness such as clozapine have an increased chance of death during treatment. Antagonists: ABT Atypical antipsychotics e. Demographics of the analysis of the cases revealed that four times as many men as women were diagnosed with cardiomyopathy. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newbornsuch as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. If your dose is 1 mL or less, use the smaller 1 mL oral syringe. Archived from the original on 10 November Follow the instructions given to you by your doctor. Dangerous side effects could occur. Antagonists: Agomelatine Atypical antipsychotics e. Thus, Cloaril occurrence of myocarditis appears to Clozrail independent of age and therefore can occur in younger patients. About About LCozaril. While you are taking Clozaril Things you must do Continue taking Clozaril as long as your doctor tells you. Careful supervision is indicated in the presence of prostatic enlargement and narrow-angle glaucoma. How Clozariil this medicine Cpozaril used? Otherwise, take it as soon as you remember, and then go back to taking it as you would normally. The tablet will quickly dissolve and can be swallowed with saliva. Atypical antipsychotics. The Journal of Clinical Psychiatry. These medicines may be affected by Clozaril or they may affect how well Clozaril works. Clozaril slide 21 of 22, Clozaril. Avoid drinking alcohol. A program has been set up by the manufacturers of clozapine to be sure that people do not take clozapine without the necessary monitoring called the Clozapine Risk Evaluation and Mitigation Strategies REMS Program. Remove the bottle cap by pushing down on the cap, then turn it counterclockwise to the left. Clozapine induces the release of glutamate and D-serinean agonist at the glycine site of the NMDA receptorfrom astrocytes[63] and reduces the expression of astrocytic glutamate transporters. Apart from drowsiness or tiredness the most common side-effects are a fast heart beat and making extra saliva.
Common use

Clozaril is an atypical antipsycotic. It is used to treat schizophrenia in patients who do not respond to other medicines. It decrease the risk of suicidal behavior. It affects certain chemicals in the brain.



Dosage and directions

Take Clozaril as prescribed by your doctor. Take it with or without food. Take with food to reduce stomach irritation if stomach upset occurs. Continue to take the medicine even if you feel well. Do not stop taking it suddenly without your doctor's advice.



Precautions

Tell your doctor about all your conditions, especially if you are pregnant or plan to become pregnant, breastfeeding, if you have any allergies, if you have a history of blood clots, blood problems, high blood cholesterol levels, heart problems, or lung or breathing problems, if you have a history of an enlarged prostate; prolonged, painful erections; liver or kidney problems; seizures (eg, epilepsy); glaucoma; stomach or bowel problems; or dementia, if you have poor health, diabetes, or a family member with diabetes, or you are very overweight, if you have decreased activity of enzymes that metabolize certain medicines.



Contraindications

You should not to take Clozaril if you have allergy to it, you have severe drowsiness, you have uncontrolled seizures (epilepsy) or loss of bowel muscle movement (paralytic ileus), you have bone marrow problems, other blood cell problems, or a history of blood problems caused by Clozaril, you are taking other medicines that may cause blood problems.



Possible side effects

The most common side effects are dry mouth, headache, dizziness, heartburn, increased sweating or saliva production, lightheadedness when you stand up; nausea; strange dreams; trouble sleeping; weight gain.

Severe side effects include: severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; calf pain or tenderness; chest pain; confusion; dark urine; decreased coordination; fainting; fast or irregular heartbeat; fever, chills, or sore throat; increased hunger, thirst, or urination; infection; involuntary movements of the tongue, face, mouth, or jaw (tongue sticking out, puffing of cheeks, mouth puckering, chewing movements); loss of appetite; numbness of an arm or leg; rapid breathing; restlessness; seizures; severe headache, dizziness, or vomiting; severe or persistent nausea or constipation; severe stomach pain; shortness of breath; stiff muscles; sudden, unusual weight gain; swelling of the hands, ankles, or feet; tremor; trouble swallowing; uncontrolled muscle movements; unusual mental or mood changes; unusual tiredness or weakness; vision changes; vomiting; yellowing of the skin or eyes.



Drug interaction

Tell your doctor about all medicines you are taking and especially: benzodiazepines (lorazepam) or other medicines for mental or mood problems because the risk of heart or breathing problems may be increased; cimetidine, erythromycin, quinolone antibiotics (ciprofloxacin), risperidone, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because they may increase the risk of Clozaril's side effects; barbiturates (phenobarbital), hydantoins (phenytoin), nicotine, or rifampin because they may decrease Clozaril's effectiveness ; antiarrhythmics (eg, propafenone, quinidine), anticholinergics (benztropine), carbamazepine, debrisoquin, dextromethorphan, medicines for depression or high blood pressure, phenothiazines (chlorpromazine), or tricyclic antidepressants (amitriptyline) because the risk of their side effects may be increased by Clozaril.



Missed dose

If you miss a dose of Clozaril, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once. If you miss taking a dose of Clozaril for more than 2 days do not start taking it again. Contact your doctor right away for instructions.



Overdose

Symptoms of overdose are drowsiness, slow or difficult breathing, dizziness, excessive salvation, fainting, coma, fast ot irregular heartbeats. If you suspect overdose seek medical attention immediately.



Storage

Store Clozaril at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clozaril out of the reach of children and away from pets.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.