Generic Cytoxan (Cyclophosphamide)
Cytoxan
Cytoxan is used for treatment of cancer with cytotoxic effect.
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Product Description
Tablets should be given with food or after meals. Therefore, blood cell counts Ctyoxan be measured approximately 10 days Cytoxn the administration of cyclophosphamide, and repeated as often as needed to insure Cytoaxn the Cytozan do not Cytoxzn too low. The faster the cells are dividing, the more likely it is that chemotherapy will kill the cells, causing the tumor to shrink. Afterwards, a medication that may be less potent with fewer side effects is used to maintain the disease in remission. The bone marrow is the organ of the body that makes red blood cells which carry oxygenwhite blood cells which fight infectionand platelets which help the blood clot. Streptomyces Actinomycin Bleomycin Mitomycins Plicamycin. Breast Cancer Treatment During Pregnancy. Periodic blood work will be obtained to monitor your complete blood count CBC as well as the function of other organs such as your kidneys and liver will also be ordered by your doctor. Cyclophosphamide has been found to significantly increase the risk of premature menopause in females and of infertility in males and females, the likelihood of which increases with cumulative drug dose and increasing patient age. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. If you have questions about side effects, call your doctor. Contact your health care provider within 24 hours of noticing any of the following:. Remain as active as you are able. After nine years, the risk falls to background. Cyclophosphamide can be taken orally daily or can be given by injection given at the doctor's office or hospital every week to every month. Breast feeding warning: Women Cjtoxan not breast Cyhoxan during treatment because this drug could enter the breast milk and badly harm a breast feeding baby. It is important to void empty your bladder frequently especially in the first 24 hours after taking cyclophosphamide. Allergic Reactions Serious allergic reactions including anaphylaxis are rare. British Journal of Haematology. Seminars in Hematology. Revised July Cyclophosphamide is also approved to be given by a shot into a muscle IMinto the abdominal lining intraperitoneal, IPor into the lining of the lung intrapleural. Cyclophosphamide has been found to significantly increase the risk of premature menopause in females and of infertility in males and females, the likelihood of which increases with cumulative drug dose and increasing patient age. This damage predisposes patients to the development of bladder cancer. Frequency not reported : Non-Hodgkin's lymphomasarcoma, renal cell carcinomarenal pelvis cancer, thyroid cancer [ Ref ]. How should this Cytoxan be used? Cyclophosphamide can be given by a number of different routes. Warts — The picture below shows a proliferation of warts in a vasculitis patient on immunosuppression. The abbreviation CP is common, although abbreviating drug names is not best practice in medicine. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. Gentle exercise is encouraged such as a daily walk. Talk to your doctor about how you are feeling during your treatment. It generally appears as white spots on the inside of the mouth pictured belowand is easily treatable with the use of anti—fungal mouthwash or troches. This is irreversible and leads to cell apoptosis. Medicine portal. Uncommon 0. Once in the cells, the prodrug was enzymatically converted into the active, toxic form. Published Dec Additional relative contraindications to the use of cyclophosphamide include lactationactive infection, neutropenia or bladder toxicity. Store Cytosan at room temperature and away from excess heat and moisture not in the bathroom. Individuals should consult a qualified health care provider for professional medical advice, Cytoxan and treatment of a medical or health condition. Medically reviewed Cytoxab Drugs. At some centers experienced in the care of patients with vasculitis and the Cytosan of cyclophosphamide, blood counts are checked every 2 weeks. View All. Cyclophosphamide Prescribing Information. Cytoxam your health care provider immediately, day or night, if you should experience any of the following symptoms:. Cyclophosphamide may cause infertility in both men and women who are treated with the medication. We discuss the possible side—effects of cyclophosphamide below. Toggle navigation. These symptoms usually can be controlled with anti-nausea medications. Note: This document contains side effect information about cyclophosphamide. Have questions about chemotherapy? Cyclophosphamide also increases the risk of developing some kinds of cancer, including lymphoma, skin and bladder cancer periodic urine tests screen for this. MESNA appears to neutralize the toxic metabolite of cyclophosphamide acrolein that is thought to be responsible for the bladder complications. Your doctor will order certain lab tests to check your body's response to cyclophosphamide. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Cyclophosphamide is used to treat cancer. Narcotic pain medicines may also be necessary for several weeks. Decreased appetite decreased hunger Blurred Cytoxzn Soreness of the mouth and throat. Cancer Research. First trimester exposure to cyclophosphamide for the treatment of cancer or lupus displays a pattern of anomalies labeled "cyclophosphamide embryopathy," including growth restrictionear and facial abnormalities, absence of digits and hypoplastic limbs. Cyclophosphamide may increase the risk that you will develop other cancers. In case of overdose, call the poison control helpline at Your doctor may recommend reliable contraception in order to prevent pregnancy while you're on this drug. The Journal of Pharmacology and Experimental Therapeutics. Individuals should consult a qualified health care provider for professional medical advice, diagnosis and treatment of Cygoxan medical or Cyttoxan condition. To protect young children from Cytoxqn, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach. Cyclophosphamide is used alone or in combination with other medications to treat Hodgkin's lymphoma Hodgkin's disease and non-Hodgkin's lymphoma types of cancer that begin in a type of white blood cells that normally fights infection ; cutaneous T-cell lymphoma CTCL, a group of cancers of the immune system that first appear as skin rashes ; multiple myeloma a type of cancer of the bone marrow ; and certain types of leukemia cancer of the white blood cellsincluding chronic lymphocytic leukemia CLLchronic myelogenous leukemia CMLacute myeloid leukemia AML, ANLLand acute lymphoblastic leukemia ALL. Philadelphia: Elsevier. Although not all of these side effects may occur, if they do occur they may need medical attention. Medication used as chemotherapy and to suppress the immune system. Ask your pharmacist any questions you have about refilling your prescription. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Monitoring and Testing While Taking Cyclophosphamide You will be checked regularly by your doctor while you are taking cyclophosphamide, to monitor side effects and check your response to therapy. Archives of Internal Medicine. Retrieved 8 December Cyclophosphamide is a pregnancy category Cytxan drug and causes Cyyoxan defects. Revised July It belongs to the class of drugs known as alkylating agents, which inhibit DNA and RNA synthesis, causing Cyttoxan death of both dividing and non-dividing tumor cells. After several cyclophosphamide treatments, she developed a marked reversible thinning of her hair. Acrolein is toxic to the bladder epithelium and can lead to hemorrhagic cystitiswhich is associated with microscopic or gross hematuria and occasionally dysuria. This bleeding may range from a few red blood cells in the urine invisible to the naked eye; only detectable by examining the urine under the microscope to life—threatening hemorrhage from the bladder. Multiple myeloma is a cancer of the bone marrow plasma cells. About About Drugs. Medicine portal. Cyclophosphamide metabolites are yCtoxan excreted in the urine unchanged, and drug dosing should be appropriately adjusted in the setting of renal dysfunction. It belongs to the yCtoxan of drugs known as Cytlxan agents, which inhibit DNA and RNA synthesis, causing the death of both Cgtoxan and non-dividing tumor cells. Report any pain or burning on urination to your health care provider. Do not breast feed while taking cyclophosphamide. For Caregivers. GVHD can often be avoided by T-cell depletion of the graft. You must check to make sure that it is safe for you to take Cytoxan cyclophosphamide injection with all of your drugs and health problems. Like other alkylating agents, cyclophosphamide is teratogenic and contraindicated in pregnant women pregnancy category D except for life-threatening circumstances in the mother. ALDHs protect these actively proliferating tissues against toxic effects of phosphoramide mustard and acrolein by converting aldophosphamide to carboxycyclophosphamide that does not give rise to the toxic metabolites phosphoramide mustard and acrolein. How Cyclophosphamide Works Chemotherapy anti-neoplastic drugs : Cancerous tumors are characterized by cell division, which is no longer controlled as it is in normal tissue. Cytoxan Images. The rash is characterized by groups of small vesicles blisters sitting on a base of reddened skin, and may be extremely painful. Cytoxan good nutrition. For general information or questionscall Take cyclophosphamide at around the same time every day. Related Content. Oral cyclophosphamide is rapidly absorbed and then converted by mixed-function oxidase enzymes cytochrome P system Cytoxqn the liver to active metabolites. Note: Not Cytooxan side effects are listed above. UPMC Hillman Cancer Center offers patients access to the latest advances in cancer prevention, detection, diagnosis, and treatment through cancer clinical trials. These symptoms may happen within a few hours after your treatment and may last up to 72 hours. Monitoring and Testing While Taking Cyclophosphamide You will be checked regularly by your doctor while you are taking cyclophosphamide, to monitor side effects and check your response to therapy. Such infertility is usually temporary, but can be permanent. High-dose intravenous cyclophosphamide can cause the syndrome of inappropriate antidiuretic hormone secretion SIADH and a potentially fatal hyponatremia when compounded by intravenous fluids administered to prevent drug-induced cystitis. Myeloma Today. Bone Marrow Transplantation. Onset: 7 days Nadir: days Recovery: 21 days Nadir: Meaning low point, nadir is the Cytoxan in time between chemotherapy cycles in which you experience low blood counts. Oral cyclophosphamide is rapidly absorbed and then converted by mixed-function oxidase enzymes cytochrome P system in the liver to active metabolites. Frequency not reported : Infertility, ovarian failure, oligomenorrhea, testicular atrophy [ Ref ]. Cyclophosphamide is a pregnancy category D drug and causes birth defects. Archived from the original on 2 January
Common use

Cytoxan belongs to the drugs for treatment of cancer with cytotoxic effect. Its active substance cyclophosphamide is converted in the liver by cytochrome P450 into two active substances acrolein and phosphoramide. They are the active compounds, and they slow the growth of cancer cells inhibiting their proliferation and metabolism. First of all this effect concerns cells of uncontrolled growing but also damages other cells of the body resulting in serious side effects. Cytoxan also can be referred to as immunosuppressive agent. Cytoxan is used to treat malignant lymphoma (lymphocytic and gistiotsitarnaya lymphoma, lymphogranulomatosis, Burkitt lymphoma, lymphoma, mixed type), multiple myeloma, leukemias (lymphocytic leukemia, granulocytic leukemia, myelocytic leukemia, acute lymphoblastic leukemia in children), neuroblastoma, ovarian adenocarcinoma, retinoblastoma, breast carcinoma.



Dosage and direction

For adults and children Cytoxan is administered intravenously by 40-50 mg/kg over 3-5 days in divided doses. An oral dose of this medication is oral dose is 1-5 mg/kg daily. Dosage should be corrected on a basis of regular blood tests for white blood cell count. This medication can be taken orally also with or without food.



Precautions

Carefulness should be exercised in patients with myelosuppression, liver or kidney disorders, with the previous radiation and chemotherapy. During treatment a regular monitoring of blood and urine count tests (for the presence of red blood cells) is required. In women of childbearing age a reliable contraception is recommended if Cytoxan is taken.



Contraindications

Hypersensitivity, severe myelosuppression.



Side effects

Side effects of Cytoxan include vulnerability to infections, the development of a secondary cancer, typically of the bladder, lymph nodes, or bone marrow. A secondary cancer may occur several years after the drug is given.



Drug interaction

Notify your doctor before to take anticancer drugs such as doxorubicin, allopurinol, and phenobarbital with Cytoxan. Correction of steroid hormones dosage should be done if they are taken with Cytoxan in patients with removed adrenal glands.



Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.



Overdose

Symptoms of Cytoxan overdose are not expected. If you suppose that took too much of it call your doctor immediately.



Storage

Store at room temperature between 20-25 C (68-77 F). Keep out of heat, moisture, sunlight, of the reach of children. Storage in a bathroom is not recommended.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. РђРїСѓ specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.