Generic Methotrexate
Methotrexate
Methotrexate is an antimetabolite used to treat certain types of cancer.
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2,5 mg x 90 pills
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Product Description
Methotrexate dosage information in more detail. Accepted Author Manuscript. Archived from the original on 8 February Methotrexate can sometimes be given along with other drugs to treat your Methotrexate. Transaminase liver enzyme levels may rise for a few days after treatment but they quickly return to normal. Most people are prescribed tablets. This condition can occur after the treatment of certain cancers. The methotrexate drug molecule is structurally similar to folic acid, which is important for making new cells. You should also carry on taking methotrexate if your symptoms improve or if you start to feel better. Using a combination of treatments can be helpful in managing severe psoriasis. By mouth, or by intravenous injection, or by intravenous infusion, or by intra-arterial infusion, or by intramuscular injection, or by intrathecal injection For Adult consult product literature. Merriam-Webster Dictionary. Dehydration or any other reason for reduced kidney function may prevent normal excretion of methotrexate resulting in toxic accumulation of the medication. How to Take It Methotrexate comes either as pills or Methotrfxate a subcutaneous injection. ILD Resources Methotrexaye living with interstitial lung disease ILD will find numerous resources listed here, offering information and support. Methotrexate can cause mouth sores. Do not drink alcohol while you are taking methotrexate. Tell your doctor if you have, or have ever had, a low blood count decrease in the number of blood cells in your bodyanemia red blood cells do not bring enough oxygen to all parts of the bodyor any other problem with your blood cells. This is known as a subcutaneous injection.

Absolutely: Methotrexate

Dapsone 765
ASTELIN 344
NIMOTOP This delay gives the methotrexate a Methottexate to exert its anti-cancer effects. You should tell your doctor or nurse specialist straight away if you notice any of the following while taking methotrexate:. Tell your doctor if any of these Mfthotrexate are severe or do not go away: dizziness drowsiness headache swollen, tender gums decreased appetite Methoyrexate eyes hair loss Some Methotrexate effects can be serious. With intrathecal use. If you are taking methotrexate to treat rheumatoid arthritis, it may take 3 to 6 weeks for your symptoms to begin to improve, and 12 weeks or longer for you to feel the full benefit of methotrexate. Show all parts of this monograph Drug action Indications and dose Unlicensed use Important safety information Contra-indications Cautions Interactions Side-effects Conception and contraception Pregnancy Breast feeding Hepatic impairment Renal impairment Pre-treatment screening Monitoring requirements Prescribing and dispensing information Patient and carer advice Medicinal forms Drug action Methotrexate inhibits the enzyme dihydrofolate reductase, essential for the synthesis of purines and pyrimidines. But speak to your nurse specialist or a doctor about this first. Monitoring and Testing: You will be checked regularly by your health care provider while you are taking methotrexate, to monitor side effects and check your response to therapy. How to tell if the drug is working: You may have signs of improvement. Your doctor may start you on a lower dosage or a different dosing schedule. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
Use the dosing syringe provided, or use a medicine dose-measuring device not a kitchen Methotrexate. It can cause problems with your electrolyte levels, which can lead to severe kidney failure or even death. You should also see your doctor urgently if you develop chickenpox or shingles, or come into contact with someone who has chickenpox or shingles. Disclaimer: Our goal is to provide you with the most relevant and current information. Seek emergency medical attention or call the Poison Help line at This effect can occur at any time during your treatment and with any dosage. You may need to have a negative pregnancy test before starting this treatment. What to do if you miss a dose: Take your dose as soon as you remember. Methotrexate can be given to people with various types of arthritis and related conditions, including:. For people with kidney disease: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. Related Drugs. Wash hands before and after removing gloves. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you are a woman, do not use methotrexate to treat psoriasis or rheumatoid arthritis if you are Mehotrexate. Individual interactants: Methotrexate. The amount Mehtotrexate methotrexate and how it is given depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition Methotrexate treated. Symptoms are; difficulty with speech, paralysis of the arms and legs, seizures, or coma. Methitrexate, folic acid is not taken on the same day methotrexate is taken. Although uncommon, methotrexate may rarely result in reactivation of tuberculosis or opportunistic bacterialfungal or viral infections. Onset: 7 days Nadir: 10 days Recovery: 21 days. However, the precautionary approach is to limit or avoid breast feeding in mothers being treated with methotrexate. Methotrexate may cause harm or death to the fetus. Methotrexate may cause a severe rash that can be life-threatening. For responding skin diseases, methotrexate usually shows some benefit within 6 to 8 weeks. If you take methotrexate by injection, it will be given into a layer of fat between the skin and muscle. Tell your doctor all the medicines you are taking, whether they are prescription or non-prescription medicines. Methotrexate may treat rheumatoid arthritis by decreasing the activity of the immune system. Methotrexate was synthesised in the s and was shown to be effective for leukaemia and several types of solid tumours. You are viewing BNF. To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals. There is still some debate as to the best dose and timing of folic acid. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Methltrexate 8-Aminoadenine Adenine. If you become pregnant while taking methotrexate, you should stop taking it and see your doctor as soon as possible. Methotrexate is one of the most effective and widely used medications Methotrexae treating inflammatory types of arthritis. Stopping treatment may not cause the Methotrexatr to go away. See smartphone apps to check your skin. Are there any alternatives? In some regions, a blood test measuring type 3 procollagen amino terminal propeptide P3NP collagen may be requested in adults aged 20—70 years before treatment with methotrexate, and repeated every 3 to 6 months while on methotrexate. We can only achieve these goals with your help. Methotrexate is an abortifacient and is commonly used to terminate pregnancies during the early stages, generally in combination with misoprostol. Methotrexate can be given to people with various types of arthritis and related conditions, including:. Aspirin and aspirin-like drugs nonsteroidal anti-inflammatories may reduce Metbotrexate much methotrexate is eliminated by the kidneys. Low-dose Methotrexate interacts with drugs that Methotrrxate the way the body uses folic acid, such as the antibiotics trimethoprim with sulfamethoxazole Bactrim, Resprim and trimethoprim alone Triprim, Alprim. It can cause problems with your electrolyte levels, which can lead to severe kidney failure or even death. A class of drugs is a group of medications that work in a similar way. This could result in dangerous side effects.
Common use

Methotrexate is an antimetabolite used to treat certain types of cancer. It inhibits dihydrofolate reductase, an important enzyme responsible for the synthesis of nucleotides for DNA. This medication inhibits synthesis of DNA, DNA reparation and cell mitosis. Cells of malignant tumor, bone marrow, embryonic cells, epithelial cells of the intestinal mucosa, bladder, oral cavity are the most sensitive to it.

Methotrexate is used in treatment of breast cancer, squamous cell carcinoma of the head and neck, lung cancer, trophoblastic tumor, cervical cancer, ovarian cancer, bladder cancer, colorectal cancer, esophagus cancer, stomach cancer, pancreatic cancer, testicular cancer, acute lymphoblastic leukemia and many others.



Dosage and direction

Take exactly as prescribed by your physician. Take Methotrexate orally with or without food. Do not chew or crush the tablet. To treat rheumatoid arthritis and psoriasis Methotrexate is taken weekly. Starting dose 7.5 mg of the medication once a week or 2.5 mg each twelve hours three times also once weekly. Treatment of cancer requires individual dosage and treatment only under control of your doctor.



Precautions

Caution should be exercised in the patients with ascites, dehydration, obstructive diseases of the digestive tract, pleural or peritoneal effusion, chronic renal failure, parasitic and infectious diseases of viral, fungal or bacterial origin due to the possible high risk of severe generalized disease development. Methotrexate toxicity increases in the individuals with herpes simplex, herpes zoster, chickenpox, measles, amoebiasis, strongyloidiasis (helminthosis caused by threadworm with allergic symptoms at the beginning of the disease), gout (also in history), infection and inflammation of mucosa in the mouth, nausea and vomiting (due to dehydration), stomach and duodenal ulcerations, ulcerative colitis, prior chemotherapy or radiotherapy, asthenia. When Metheotrexate is used to treat cancer cautiousness is need in the patients with aciduria (urine pH less than 7) and inhibited bone marrow hematopoiesis. Do not expose yourself to sun rays. Immunization by vaccines should be avoided for 3-12 months since the course of treatment with Methotrexate was finished. Men and women should use safe contraception as this drug is very toxic for an unborn baby.



Contraindications

This medicine cannot be administered to the patients with hypersensitivity to its components, immune deficiency, pregnant and breastfeeding women. When Methotrexate is used to treat patents with psoriasis or rheumatic diseases it cannot be used if they also have heavy suppression of bone marrow hematopoiesis, severe kidney or liver failure.



Possible side effect

Methotrexate is usually well tolerated but some patients may develop mouth sores, stomach upset, and low white blood counts. Methotrexate is known to be toxic to the liver, kidneys, lung and bone marrow. Blood tests should be done on a regular basis while treatment with this drug. Other adverse reactions may include headache, drowsiness and allergic reactions such as skin rash, itching, dizziness, and hair loss.



Drug interaction

Inform your doctor about all prescribed and over-the-counter medications, herbal products and food supplements you take and especially about NSAIDs such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), naproxen (Aleve, Naprosyn), etodolac (Lodine), indomethacin (Indocin), meloxicam (Mobic), piroxicam (Feldene) as they increase Methotrexate toxicity); azathioprine (Imuran). Use of anti-gout drugs (allopurinol, colchicine, sulfinpirazon) requires correction of the dose. Inform your doctor also about chloramphenicol (Chloromycetin), hydroxychloroquine (Plaquenil, Quineprox), retinol, tretinoin (Retin-A), isotretinoin (Accutane), steroids (prednisone and others), sulfa drugs (Bactrim, Septra, Azulfidine), phenytoin (Dilantin), theophylline (Theobid, Theo-Dur, Elixophyllin, Slo-Bid), probenecid (Benemid), tetracycline (Brodspec, Panmycin, Sumycin, Tetracap), oral anti-diabetes drugs such as glipizide (Glucotrol), chlorpropamide (Diabinese), acetohexamide (Dymelor), glimepiride (Amaryl), or tolbutamide (Orinase), a penicillin antibiotics, salicylates (Dolobid, Salflex, Tricosal, Disalcid, Doan's Pills).



Missed dose

Consult your doctor if you miss a dose of this medicine.



Overdose

Contact your doctor immediately if you suspect overdose. Signs of overdose include nausea, vomiting, weakness, paleness, easy bruising or bleeding, mouth sores, black or bloody stools, coughing up blood, vomit similar to coffee grounds, decreased urination or anuria.



Storage

Store in a dry tight container away from sunlight at room temperature between 15-30 C (59-86 F) away from children and pets.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.