Generic Prandin (Repaglinide)
Prandin
Prandin is used to stimulate insulin secretion from the pancreas in treatment of type 2 of diabetes mellitus.
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Product Description

Prandin - you tell

Repaglinide causes the beta cells to produce more insulin. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Sign up now. It's used to treat people with type 2 diabetes who can't manage their condition by diet and exercise alone. Last updated on Jun 24, More From Diabetes. There was no increase in frequency or severity of hypoglycemia in older subjects, but greater sensitivity of some older individuals to PRANDIN therapy cannot be ruled out. Please inform your doctor or pharmacist if you have previously experienced such an allergy. There was an average reduction in hemoglobin A1c levels of 1. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure convulsions. Enter Zip Code GoodRx. Call your doctor for medical advice about side effects. All rights reserved. Low blood sugar hypoglycaemia may occur as a side effect of repaglinide. Blockers Glibenclamide Lonidamine Piretanide. Patient Platform Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. Increased risk of hypoglycemia with changes in physical activity, meal patterns, renal or hepatic impairment: monitor glucose more frequently and may need to adjust dose. Repaglinide lowers blood glucose levels by stimulating the release of insulin from the pancreas. Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. In one-year, active-controlled trials, no differences were seen in effectiveness or adverse events between these subjects and those less than Not for use with NPH-insulin possible myocardial ischemia. Concomitant cyclosporine: max 6mg daily. Increased risk of hypoglycemia with changes in physical activity, meal patterns, renal or hepatic impairment: monitor glucose more frequently and may need to adjust dose. By using this site you agree to our use of cookies. Don't stop it without talking to your doctor. This new patent was due to expire June Prandin RSS. Abdominal pain. Allergic skin reactions such as rash and itch. Explore now. Mayo Clinic does not endorse companies or products. Tell your healthcare provider about any signs or symptoms of hypersensitivity, which include the following: chest pain Prandin of the face, eyes, lips, tongue, arms, or legs difficulty breathing or swallowing fainting rash Do not take Prandin if you: are allergic to any of its ingredients have a condition called diabetic ketoacidosis have type 1 diabetes take a medication called gemfibrozil Lopid. From Wikipedia, the free encyclopedia. There were six serious adverse events of myocardial ischemia in patients treated with PRANDIN plus NPH-insulin from two studies, and one event in patients using insulin formulations alone from another study [see Warnings and Precautions 5. In Januarya federal court ruled Novo Nordisk's new patent invalid on the grounds of obviousness, and unenforceable on the grounds of inequitable conduct on the part of Novo Nordisk's patent attorneys. Prandin RSS. Blockers Glibenclamide Lonidamine Piretanide. Repaglinide was non-genotoxic in a battery of in vivo and in vitro studies: Bacterial mutagenesis Ames testin vitro forward cell mutation assay in V79 cells HGPRTin vitro chromosomal aberration assay in human lymphocytes, unscheduled and replicating DNA synthesis in rat liver, and in vivo mouse and rat micronucleus tests. PRANDIN is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Metabolism: repaglinide is primarily metabolized by the liver - specifically CYP 2C8 and 3A4 - and to a lesser extent via glucuronidation. L-type-selective : Bay K Protect from moisture. General Information Prandin repaglinide has been approved for the treatment of Type 2 diabetes. Caution should be taken in people with liver disease and decreased kidney function when using this medication. Drug Class. The following medicines may affect the blood level of repaglinide and so could change its effect at controlling blood sugar: carbamazepine phenobarbital phenytoin rifampicin PPrandin herbal remedy St John's wort Hypericum perforatum. Prandin PPrandin. You can browse Drugs A-Z for Prandin specific prescription or over-the-counter drug or look up Prandim based on your specific condition. The table below contains some of the most common ones associated with repaglinide. Explore Apps. No pharmacokinetic studies to assess the effects of race have been performed, but in a U. Take repaglinide 15 minutes before each of your main meals. Other medicines containing the same active ingredient Repaglinide tablets are also available without a brand name, ie as the generic medicine. This may result in low blood sugar episodes, high blood sugar episodes, or both. Prandin is only part of a complete program of treatment that also includes diet, exercise, and weight control. It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Only 0. Take Prandin before each meal. Common affect between 1 in 10 and 1 in people Low blood sugar level hypoglycaemia. If you have any questions about this medicine ask your pharmacist. The maximum daily dose is 16 mg. Patients with renal or hepatic impairment Prandun be at higher risk of hypoglycemia [see Use in Specific Populations 8. Always consult your healthcare provider to ensure the Prandun displayed on this page applies to your personal circumstances. Neither Everyday Health nor its licensors endorse drugs, diagnose patients or recommend therapy. Tell your healthcare provider right away if you have some or all of the following symptoms of high blood sugar :. Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Drugs that are known to inhibit CYP3A4 include antifungal agents ketoconazole, itraconazole and antibacterial agents clarithromycin, erythromycin. FDA alerts for all medications. If you start treatment with any of these your dose of repaglinide may subsequently need increasing:. Allergic skin reactions such as rash and itch. A repaglinide overdose can cause life-threatening hypoglycemia. Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially those listed in the Warning section or any of the following:. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda. Prandin is a prescription medication used with diet and exercise to treat type 2 Pfandin. Patents 5, and 5, would be 5 September These data indicate Ptandin repaglinide did not accumulate in serum. I accept the Terms and Privacy Policy. Marketing Information. The Prandin dose your doctor recommends will be based on the following: other medical conditions you have other medications you are taking how you respond to the medication The recommended dose range of Prandin for the treatment of type 2 diabetes is 0.

Prandin - can

How to store repaglinide Important information about all medicines. Tell each of your health care providers about Pranein medicines you use now and any medicine you start or stop using. Many other medicines that can increase or decrease the effects of repaglinide n lowering your blood sugar. Common adverse events include: [1]. Approximately of these individuals with type 2 diabetes have been treated for at least Prxndin months, for at least 6 months, and for at least 1 year. Patients with severely reduced renal function had elevated mean AUC and C max values Do not take extra medicine to make up the missed dose. Email Address. Low blood sugar hypoglycemia can happen to everyone who has diabetes. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Tell your healthcare provider about any signs or symptoms of hypersensitivity, which include the following:. We use cookies to provide you with a better experience. It's also not known if repaglinide is found in breast milk. Patients and caregivers must be educated to recognize and manage hypoglycemia. Your Personal Message. Common repaglinide side-effects these affect less than 1 in 10 people What can I do if I experience this. Take Prandin before each meal. Prandin Drug Class Back to Top. If you start treatment with any of these your dose of repaglinide may subsequently need increasing: asthma relievers beta 2 agonistseg salbutamol corticosteroidseg hydrocortisone, prednisolone diureticsespecially thiazide diuretics, eg bendroflumethiazide danazol oestrogens and progestogens, such as those contained in oral contraceptives thyroid hormoneseg thyroxine. PRANDIN is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. In a double-blind, placebo-controlled, 3-month dose titration study, PRANDIN or placebo doses for each patient were increased weekly from 0. Repaglinide is completely metabolized by oxidative biotransformation and direct conjugation with glucuronic acid after either an IV or oral dose. In clinical studies of 24 weeks or greater duration, patients were over 65 years of age and no patients were greater than 75 years of age. Increased frequency of glucose monitoring may be required during concomitant use. Equally, if you have an extra meal, you should add an extra repaglinide dose for that meal. Marketing Information. People with diabetes need treatment to control the amount of sugar in their blood. Clinical Impact:. This medication may be prescribed for other uses. Not for use with NPH-insulin possible myocardial ischemia. Drug Class. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure convulsions. Along with its needed effects, a medicine may cause some unwanted effects. Prandin Food Interactions Back to Top. Prandin is used together with diet and exercise to improve blood sugar control in adults Prndin type 2 diabetes mellitus. All rights Pranddin. Jardiance empagliflozin. You should take precautions to avoid low blood sugar when driving - discuss this with your doctor. Prandin helps the pancreas to produce more insulin at mealtimes Prandin is used to control type-2 diabetes. Expand section Collapse section. Common repaglinide side-effects these affect less than 1 in 10 people What can I do if I experience this? Prandin dosage information in more detail. Table of contents Overview Authorisation details Product information Assessment history. Regenerative Medicine: Steps to Accelerate Development. Prandin Profile. Follow your doctor's instructions about using Prandin if you are pregnant. Looking to lose weight this year? The dose that achieved the targeted control or the maximum dose was continued to end of study. Across seven controlled trials, there were six serious adverse events of myocardial ischemia in patients treated with PRANDIN plus NPH-insulin from two studies, and one event in patients using insulin formulations alone from another study [see Adverse Reactions 6. In a double-blind, placebo-controlled, 3-month dose titration study, PRANDIN or placebo doses for each patient were increased weekly from 0. Most of the fasting blood glucose-lowering effect was demonstrated within 1 to 2 weeks. Low blood sugar hypoglycaemia may occur as a side effect of repaglinide. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment may occur and constitute medical emergencies requiring immediate hospitalization.
Common use

Prandin contains active component Repaglinide which is used to stimulate insulin secretion from the pancreas in treatment of type 2 of diabetes mellitus together with a diet therapy and physical activities including combined treatment with metformin.



Dosage and direction

The medication is taken orally 15-30 minutes before a meal usually 3 times a day. Dosage is administered individually. Initial recommended dose is 0.5 mg. The dose may be increased only after 1-2 weeks of treatment if blood glucose levels require it. The maximum single dose is 4 mg, maximal daily dose is 16 mg. If the patient has taken other oral diabetes drug the recommended initial dose is 1 mg.



Precautions

Inform your doctor or pharmacist if you have liver impairments, kidney failure or disorders. The medication should be used with cautiousness in weakened patients and in patients before future major surgery.



Contraindications

Hypersensitivity, diabetes mellitus type 1, diabetic ketoacidosis with or without coma, severe liver dysfunction and/or kidney disease, pregnancy, breast-feeding. Prandin cannot be used in children and patients older than 75 y.o.



Side effects

Hypoglycemia,visual acuity loss, dyspepsia, transient increase in liver enzymes, allergic reactions.



Drug interaction

Beta-blockers, chloramphenicol, indirect anticoagulants (coumarin derivatives), NSAIDs, probenecid, salicylates, MAO inhibitors, sulfonamides, alcohol, anabolic steroids increase, calcium channel blockers, corticosteroids, diuretics (especially thiazide), isoniazid, niacin, oral contraceptives, phenothiazines, phenytoin, sympathomimetics, thyroid hormones weaken the effects of Prandin. Erythromycin, ketoconazole and miconazole slow down metabolism of Prandin while barbiturates, carbamazepine and rifampin stimulate it.



Missed dose

Take the missed dose as soon as you remember. If it is almost time of your next dose just skip the missed dose and return to your schedule. Do not double dose this medication to make up the missed dose.



Overdose

Symptoms of overdose include: hypoglycemia (hunger, fatigue and weakness, headache, irritability, anxiety, drowsiness, restless sleep, nightmares, behavioral changes (similar to ones observed during alcohol intoxication), poor concentration, slurred speech, vision problems, confusion, pallor, nausea, palpitations, cramps, cold sweats, coma, etc.



Storage

Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Women's Health

Talking about women's health we usually mean a number of issues that are associated with women's physiology and anatomy. These issues usually includes gynecological diseases, pregnancy and breastfeeding, menopause, contraception and diseases that are peculiar only to women sex.

Gynecological diseases usually includes infectious diseases that are transmitted through the sexual intercourse. These may be viral, bacterial or fungal infection. The gynecological infections usually manifest in the form of inflammation, edema, redness, itching, discharges, pain in the pelvic area.

Menstruation, pregnancy and breastfeeding are related to the women's reproductive system. Menstruation is a physiological process manifested in rejection of the functional endomethrium layer and vaginal bleeding. Usually a women have a regular menstrual cycle. The disorders of the menstrual cycle can be caused by the hormonal changes, infectious diseases.

Pregnancy includes such issues as

  • Impregnation
  • Carrying of pregnancy and those changes that take place in the women's organism during the pregnancy
  • Act of delivery

If we talk about women's health in women over 45 years we usually talk about 2 conditions : menopause and osteoporosis. Menopause is a period in the women's health when her menstruation stops. In this period a women's organism begins to produce less sex hormones such as estrogens and progestogens. In this period many women complain on hot flashes, night sweats and others. In the period of menopause women usually relieve hormonal replacement therapy.

Another condition that is closely related to menopause is osteoporosis. Osteoporosis is a disease of the bones that becomes fragile and more susceptible to fractures. The treatment of osteoporosis includes life style changes, proper nutrition and certain medication such as Fosamax and Evista.